JNJ-10181457
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574759

CAS#: 544707-20-2

Description: JNJ-10181457 is an antagonist of histamine H3 receptors that increases extracellular norepinephrine and acetylcholine levels in the frontal cortex.


Chemical Structure

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JNJ-10181457
CAS# 544707-20-2

Theoretical Analysis

MedKoo Cat#: 574759
Name: JNJ-10181457
CAS#: 544707-20-2
Chemical Formula: C20H30Cl2N2O
Exact Mass: 384.1735
Molecular Weight: 385.37
Elemental Analysis: C, 62.33; H, 7.85; Cl, 18.40; N, 7.27; O, 4.15

Price and Availability

Size Price Availability Quantity
1.0mg USD 225.0 2 Weeks
5.0mg USD 475.0 2 Weeks
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Synonym: JNJ-10181457; RWJ 662733

IUPAC/Chemical Name: 4-[[3-[4-(1-piperidinyl)-1-butyn-1-yl]phenyl]methyl]-morpholine, dihydrochloride

InChi Key: HDRIBIYPLKZUDQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H28N2O/c1-3-10-21(11-4-1)12-5-2-7-19-8-6-9-20(17-19)18-22-13-15-23-16-14-22/h6,8-9,17H,1,3-5,10-16,18H2

SMILES Code: N1(CC2=CC=CC(C#CCCN3CCCCC3)=C2)CCOCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 385.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Bonaventure, P., Letavic, M., Dugovic, C., et al. Histamine H3 receptor antagonists: From target identification to drug leads. Biochem. Pharmacol. 73(8), 1084-1096 (2007).

2. Mohsen, A., Yoshikawa, T., Miura, Y., et al. Mechanism of the histamine H3 receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice. Neuropharmacology 81, 188-194 (2014).

3. Iida, T., Yoshikawa, T., Kárpáti, A., et al. JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice. Biochem. Biophys. Res. Commun. 488(3), 534-540 (2017).