WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574759
CAS#: 544707-20-2
Description: JNJ-10181457 is an antagonist of histamine H3 receptors that increases extracellular norepinephrine and acetylcholine levels in the frontal cortex.
MedKoo Cat#: 574759
Name: JNJ-10181457
CAS#: 544707-20-2
Chemical Formula: C20H30Cl2N2O
Exact Mass: 384.1735
Molecular Weight: 385.37
Elemental Analysis: C, 62.33; H, 7.85; Cl, 18.40; N, 7.27; O, 4.15
Synonym: JNJ-10181457; RWJ 662733
IUPAC/Chemical Name: 4-[[3-[4-(1-piperidinyl)-1-butyn-1-yl]phenyl]methyl]-morpholine, dihydrochloride
InChi Key: HDRIBIYPLKZUDQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H28N2O/c1-3-10-21(11-4-1)12-5-2-7-19-8-6-9-20(17-19)18-22-13-15-23-16-14-22/h6,8-9,17H,1,3-5,10-16,18H2
SMILES Code: N1(CC2=CC=CC(C#CCCN3CCCCC3)=C2)CCOCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 385.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Bonaventure, P., Letavic, M., Dugovic, C., et al. Histamine H3 receptor antagonists: From target identification to drug leads. Biochem. Pharmacol. 73(8), 1084-1096 (2007).
2. Mohsen, A., Yoshikawa, T., Miura, Y., et al. Mechanism of the histamine H3 receptor-mediated increase in exploratory locomotor activity and anxiety-like behaviours in mice. Neuropharmacology 81, 188-194 (2014).
3. Iida, T., Yoshikawa, T., Kárpáti, A., et al. JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice. Biochem. Biophys. Res. Commun. 488(3), 534-540 (2017).
