WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574743
Description: I-CBP112 hydrochlorideis a selective inhibitor of CBP and EP300 that directly binds their bromodomains.
MedKoo Cat#: 574743
Name: I-CBP112 hydrochloride
Chemical Formula: C27H37ClN2O5
Exact Mass: 504.2391
Molecular Weight: 505.05
Elemental Analysis: C, 64.21; H, 7.38; Cl, 7.02; N, 5.55; O, 15.84
Synonym: I-CBP112 hydrochloride; I-CBP112 HCl
IUPAC/Chemical Name: 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl]methoxy]-1,4-benzoxazepin-4(5H)-yl]-1-propanone, monohydrochloride
InChi Key: NZYYXGVOYOZTHZ-FYZYNONXSA-N
InChi Code: InChI=1S/C27H36N2O5.ClH/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19;/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3;1H/t19-;/m0./s1
SMILES Code: COC1=C(OC)C=C(C2=CC(OC[C@H]3CCCN(C)C3)=C(OCCN(C(CC)=O)C4)C4=C2)C=C1.Cl
Appearance: Solid powder
Purity: >90% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 505.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Iyer, N.G., Özdag, H., and Caldas, C. p300/CBP and cancer. Oncogene 23, 4225-4231 (2004).
2. Kalkhoven, E. CBP and p300: HATs for different occasions. Biochemical Pharmacology 68, 1145-1155 (2004).
3. Zeng, L., Zhang, Q., Gerona-Navarro, G., et al. Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure 16(4), 643-652 (2008).