WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462873
CAS#: 75587-96-1
Description: U-56324 is a hypoglycemic agent derived from nicotinic acid. It was found to inhibit the activity of ATP-sensitive potassium channels in excised patches from mouse pancreatic B-cells.
MedKoo Cat#: 462873
Name: U 56324
CAS#: 75587-96-1
Chemical Formula: C11H15NO3
Exact Mass: 209.1052
Molecular Weight: 209.245
Elemental Analysis: C, 63.14; H, 7.23; N, 6.69; O, 22.94
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Synonym: U-56324; Dhnpona;
IUPAC/Chemical Name: 6-neopentyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
InChi Key: FRHCVEBCJCHBAI-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H15NO3/c1-11(2,3)6-7-4-5-8(10(14)15)9(13)12-7/h4-5H,6H2,1-3H3,(H,12,13)(H,14,15)
SMILES Code: CC(C)(CC1=CC=C(C(N1)=O)C(O)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 209.245 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hopkins WF, Fatherazi S, Cook DL. The oral hypoglycemic agent, U-56324, inhibits the activity of ATP-sensitive potassium channels in cell-free membrane patches from cultured mouse pancreatic B-cells. FEBS Lett. 1990 Dec 17;277(1-2):101-4. doi: 10.1016/0014-5793(90)80818-4. PMID: 2269336.
