WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462869
CAS#: 33089-74-6
Description: U-40481 reduced the rate of both 45Ca uptake and norepinephrine-stimulated 45Ca uptake into deadventitiated rabbit aorta strips and reduced NE-stimulated efflux from 45Ca-loaded, superfused aorta strips.
MedKoo Cat#: 462869
Name: U-40481
CAS#: 33089-74-6
Chemical Formula: C10H14N2
Exact Mass: 162.1157
Molecular Weight: 162.236
Elemental Analysis: C, 74.03; H, 8.70; N, 17.27
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Note: Price will be listed if it is available in the future.
Synonym: U-40481; U 40481A; NSC363957; NSC-363957; NSC 363957;
IUPAC/Chemical Name: (E)-N-(2,4-dimethylphenyl)-N'-methylformimidamide
InChi Key: JIIOLEGNERQDIP-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H14N2/c1-8-4-5-10(9(2)6-8)12-7-11-3/h4-7H,1-3H3,(H,11,12)
SMILES Code: C/N=C/Nc1c(C)cc(C)cc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 162.236 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Moyano P, Ruiz M, García JM, Frejo MT, Anadon Baselga MJ, Lobo M, García J, Del Pino J. Oxidative stress and cell death induction by amitraz and its metabolite BTS-27271 mediated through cytochrome P450 and NRF2 pathway alteration in primary hippocampal cell. Food Chem Toxicol. 2019 Jul;129:87-96. doi: 10.1016/j.fct.2019.04.042. Epub 2019 Apr 25. PMID: 31029719.
2: Hu SX, Benner CP, White JA, Martin RA, Feenstra KL. Pharmacokinetics and brain distribution of amitraz and its metabolites in rats. Environ Toxicol Pharmacol. 2019 Jan;65:40-45. doi: 10.1016/j.etap.2018.11.005. Epub 2018 Nov 23. PMID: 30503806.
3: Gross AD, Temeyer KB, Day TA, Pérez de León AA, Kimber MJ, Coats JR. Pharmacological characterization of a tyramine receptor from the southern cattle tick, Rhipicephalus (Boophilus) microplus. Insect Biochem Mol Biol. 2015 Aug;63:47-53. doi: 10.1016/j.ibmb.2015.04.008. Epub 2015 May 6. PMID: 25958152.
4: Ferrer C, Agüera A, Mezcua M, Fernández-Alba AR, Mack D, Anastassiades M, Gamón M. Efficiency evaluation of the main multiresidue methods used in Europe for the analysis of amitraz and its major metabolites. J AOAC Int. 2010 Mar- Apr;93(2):380-8. PMID: 20480882.
5: Lehner AF, Hughes CG, Karpiesiuk W, Harkins JD, Dirikolu L, Bosken J, Camargo F, Boyles J, Troppmann A, Woods WE, Tobin T. Development of a method for the detection and confirmation of the alpha-2 agonist amitraz and its major metabolite in horse urine. J Anal Toxicol. 2004 Oct;28(7):553-62. doi: 10.1093/jat/28.7.553. PMID: 15516314.
6: Naikai Z, Xiuying D, Xijuan X, Shuqin W, Fengchun A. Metabolic conversion of N'-(2,4-dimethylphenyl)-N-methylformamidine pesticide and the analysis of the metabolites. Bull Environ Contam Toxicol. 2000 Jul;65(1):22-7. doi: 10.1007/s0012800089. PMID: 10874075.
7: Abu-Basha EA, Yibchok-Anun S, Hopper DL, Hsu WH. Effects of the pesticide amitraz and its metabolite BTS 27271 on insulin and glucagon secretion from the perfused rat pancreas: involvement of alpha2D-adrenergic receptors. Metabolism. 1999 Nov;48(11):1461-9. doi: 10.1016/s0026-0495(99)90160-9. PMID: 10582558.
8: Pass MA, Mogg TD. Pharmacokinetics and metabolism of amitraz in ponies and sheep. J Vet Pharmacol Ther. 1995 Jun;18(3):210-5. doi: 10.1111/j.1365-2885.1995.tb00580.x. PMID: 7674457.
9: Chen TH, Hsu WH. Inhibition of insulin release by a formamidine pesticide amitraz and its metabolites in a rat beta-cell line: an action mediated by alpha-2 adrenoceptors, a GTP-binding protein and a decrease in cyclic AMP. J Pharmacol Exp Ther. 1994 Dec;271(3):1240-5. PMID: 7527851.
10: Shin DH, Hsu WH. Influence of the formamidine pesticide amitraz and its metabolites on porcine myometrial contractility: involvement of alpha 2-adrenoceptors and Ca2+ channels. Toxicol Appl Pharmacol. 1994 Sep;128(1):45-9. doi: 10.1006/taap.1994.1178. PMID: 8079353.
11: Pass MA, Mogg TD. Effect of amitraz and its metabolites on intestinal motility. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(1-2):169-72. doi: 10.1016/0742-8413(91)90095-b. PMID: 1675967.
12: Liu MY, Plapp FW Jr. Formamidines as synergists of cypermethrin in susceptible and pyrethroid resistant house flies (Diptera: Muscidae). J Econ Entomol. 1990 Dec;83(6):2181-6. doi: 10.1093/jee/83.6.2181. PMID: 2280046.
13: Ravikumar VC, Rieger JA. Potential neuromuscular toxicity of N'-(2,4-xylyl)-N-methyl formamidine HCl in rodents. Toxicology. 1983 May;27(1):71-80. doi: 10.1016/0300-483x(83)90076-8. PMID: 6679938.
14: Knowles CO, Benezet HJ. Excretion balance, metabolic fate and tissue residues following treatment of rats with amitraz and N'-(2,4-dimethylphenyl)-N-methylformamidine. J Environ Sci Health B. 1981;16(5 Pt B):547-55. doi: 10.1080/03601238109372278. PMID: 7299070.
15: Robinson CP, Pento JT. The effects of U-40481, demethylchlordimeform, and formetanate on calcium flux in the isolated rabbit aorta. Res Commun Chem Pathol Pharmacol. 1980 May;28(2):215-28. PMID: 6771843.
