U 89232

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462842

CAS#: 134017-78-0

Description: U 89232 is a derivative of the ATP-sensitive potassium channel opener cromakalim. It also has cardioselective properties.


Chemical Structure

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U 89232
CAS# 134017-78-0

Theoretical Analysis

MedKoo Cat#: 462842
Name: U 89232
CAS#: 134017-78-0
Chemical Formula: C19H25N5O2
Exact Mass: 355.20
Molecular Weight: 355.442
Elemental Analysis: C, 64.20; H, 7.09; N, 19.70; O, 9.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: U-89232;

IUPAC/Chemical Name: Guanidine, N-cyano-N'-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl)-N''-(1,1-dimethylpropyl)-,

InChi Key: XOYZVGFXSLYSCF-JKSUJKDBSA-N

InChi Code: InChI=1S/C19H25N5O2/c1-6-18(2,3)24-17(22-11-21)23-15-13-9-12(10-20)7-8-14(13)26-19(4,5)16(15)25/h7-9,15-16,25H,6H2,1-5H3,(H2,22,23,24)/t15-,16+/m0/s1

SMILES Code: CC1(C)OC2=CC=C(C#N)C=C2[C@H](N/C(NC#N)=N\C(CC)(C)C)[C@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 355.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rohmann S, Fuchs C, Schelling P. In swine myocardium, the infarct size reduction induced by U-89232 is glibenclamide sensitive: evidence that U-89232 is a cardioselective opener of ATP-sensitive potassium channels. J Cardiovasc Pharmacol. 1997 Jan;29(1):69-74. doi: 10.1097/00005344-199701000-00011. PMID: 9007673.

2: Norman NR, Toombs CF, Khan SA, Buchanan LV, Cimini MG, Gibson JK, Meisheri KD, Shebuski RJ. Comparative effects of the potassium channel openers cromakalim and pinacidil and the cromakalim analog U-89232 on isolated vascular and cardiac tissue. Pharmacology. 1994 Aug;49(2):86-95. doi: 10.1159/000139220. PMID: 7972325.

3: Toombs CF, Moore TL, Shebuski RJ. Cardioprotection with U-89232 is not reversible with glibenclamide: evidence of a novel anti-ischemic agent derived from cromakalim. Pharmacology. 1994 Aug;49(2):96-104. doi: 10.1159/000139221. PMID: 7972326.

4: Toombs CF, Norman NR, Groppi VE, Lee KS, Gadwood RC, Shebuski RJ. Limitation of myocardial injury with the potassium channel opener cromakalim and the nonvasoactive analog U-89,232: vascular vs. cardiac actions in vitro and in vivo. J Pharmacol Exp Ther. 1992 Dec;263(3):1261-8. PMID: 1469632.