U 86983

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462841

CAS#: 130736-65-1

Description: U 86983 is an antiproliferative 2-aminochromone.

Chemical Structure

img
U 86983
CAS# 130736-65-1
Instruction

Theoretical Analysis

MedKoo Cat#: 462841
Name: U 86983
CAS#: 130736-65-1
Chemical Formula: C19H18N2O4
Exact Mass: 338.13
Molecular Weight: 338.363
Elemental Analysis: C, 67.45; H, 5.36; N, 8.28; O, 18.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: U-86983;

IUPAC/Chemical Name: 2-morpholino-8-(pyridin-3-ylmethoxy)-4H-chromen-4-one

InChi Key: XBWOPIBIKIFENU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18N2O4/c22-16-11-18(21-7-9-23-10-8-21)25-19-15(16)4-1-5-17(19)24-13-14-3-2-6-20-12-14/h1-6,11-12H,7-10,13H2

SMILES Code: O=C1C=C(N2CCOCC2)Oc3c1cccc3OCc4cnccc4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 338.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Erickson LA, Bonin PD, Wishka DG, Morris J, Dalga RJ, Williams DJ, Wilson GJ, Hoover JL, Simmons CA, Humphrey SJ, et al. In vitro and in vivo inhibition of rat vascular smooth muscle cell migration and proliferation by a 2-aminochromone U-86983. J Pharmacol Exp Ther. 1994 Oct;271(1):415-21. PMID: 7965742.

2: Labhasetwar V, Song C, Humphrey W, Shebuski R, Levy RJ. Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J Pharm Sci. 1998 Oct;87(10):1229-34. doi: 10.1021/js980021f. PMID: 9758682.

3: Song LP, Yang J, Wang H, Sun HF, Tang LN, Wu L, Chang J, Song CX. [Influence of water-soluble additives on drug release kinetics from biodegradable poly(lactic-co-glycolic acid) matrix]. Yao Xue Xue Bao. 2005 Jun;40(6):557-62. Chinese. PMID: 16144325.

4: Song C, Labhasetwar V, Cui X, Underwood T, Levy RJ. Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model. J Control Release. 1998 Jul 31;54(2):201-11. doi: 10.1016/s0168-3659(98)00016-9. PMID: 9724907.