WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574708
CAS#: 67469-45-8
Description: GBR-13069 dihydrochloride is a dopamine reuptake inhibitor.
MedKoo Cat#: 574708
Name: GBR-13069 dihydrochloride
CAS#: 67469-45-8
Chemical Formula: C28H32Cl2F2N2O
Exact Mass:
Molecular Weight: 521.4738
Elemental Analysis: C, 64.49; H, 6.19; Cl, 13.60; F, 7.29; N, 5.37; O, 3.07
Synonym: GBR-13069 dihydrochloride; GBR-13069 2HCl
IUPAC/Chemical Name: 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine dihydrochloride
InChi Key: ZBSZWEYIIGLGSX-RDRKJGRWSA-N
InChi Code: InChI=1S/C28H30F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-15,28H,16-22H2;2*1H/b7-4+;;
SMILES Code: FC1=CC=C(C(C2=CC=C(F)C=C2)OCCN3CCN(C/C=C/C4=CC=CC=C4)CC3)C=C1.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
| Biological target: | GBR 13069 dihydrochloride is a potent inhibitor of dopamine uptake (IC50 = 40 nM). |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
The following data is based on the product molecular weight 521.4738 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
1. Heikkila RE, Manzino L. Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur J Pharmacol. 1984;103(3-4):241-248. doi:10.1016/0014-2999(84)90483-7
