WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462808
CAS#: 1881-07-8
Description: U 24067 is an angiostatic steroid.
MedKoo Cat#: 462808
Name: U 24067
CAS#: 1881-07-8
Chemical Formula: C24H31FO5
Exact Mass: 418.2156
Molecular Weight: 418.5054
Elemental Analysis: C, 68.88; H, 7.47; F, 4.54; O, 19.11
This product is not in stock, which may be available by custom synthesis.
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Synonym: EINECS 217-536-8;
IUPAC/Chemical Name: 2-((6S,8S,10R,13S,14S,16R,17R)-6-fluoro-17-hydroxy-10,13,16-trimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
InChi Key: YOLRNVJDBSRWRR-MQANLOPGSA-N
InChi Code: InChI=1S/C24H31FO5/c1-13-9-18-16-11-20(25)19-10-15(27)5-7-22(19,3)17(16)6-8-23(18,4)24(13,29)21(28)12-30-14(2)26/h6,10,13,16,18,20,29H,5,7-9,11-12H2,1-4H3/t13-,16-,18+,20+,22-,23+,24+/m1/s1
SMILES Code: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(CC[C@@]4(C3=CC[C@@]2([C@]1(C(COC(C)=O)=O)O)C)C)=O)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 418.5054 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hori Y, Hu DE, Yasui K, Smither RL, Gresham GA, Fan TP. Differential effects of angiostatic steroids and dexamethasone on angiogenesis and cytokine levels in rat sponge implants. Br J Pharmacol. 1996 Aug;118(7):1584-91. doi: 10.1111/j.1476-5381.1996.tb15578.x. PMID: 8842418; PMCID: PMC1909851.
2: Pepper MS, Vassalli JD, Wilks JW, Schweigerer L, Orci L, Montesano R. Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis. J Cell Biochem. 1994 Aug;55(4):419-34. doi: 10.1002/jcb.240550403. PMID: 7525617.
3: Nguyen M, Shing Y, Folkman J. Quantitation of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane. Microvasc Res. 1994 Jan;47(1):31-40. doi: 10.1006/mvre.1994.1003. PMID: 7517489.
