DSN28369
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555834

CAS#: 2413428-36-9

Description: DSN28369 is a heterobifunctional linker, and useful to make antibody drug conjuate (ADC). DSN28369 contains a carboxy group, which can react with amino group or hydroxy group after activation. DSN28369 also contains a maleimido group, which can react with surfuryl group. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).


Chemical Structure

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DSN28369
CAS# 2413428-36-9

Theoretical Analysis

MedKoo Cat#: 555834
Name: DSN28369
CAS#: 2413428-36-9
Chemical Formula: C25H31N5O8
Exact Mass: 529.22
Molecular Weight: 529.550
Elemental Analysis: C, 56.70; H, 5.90; N, 13.23; O, 24.17

Price and Availability

Size Price Availability Quantity
100mg USD 650 2 Weeks
250mg USD 1450 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3650 2 Weeks
2g USD 6450 2 Weeks
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Related CAS #: 2413428-36-9    

Synonym: DSN28369; DSN-28369; DSN 28369;

IUPAC/Chemical Name: (6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl)glycylglycyl-L-phenylalanylglycine

InChi Key: DWPLKZYCOGLRPC-SFHVURJKSA-N

InChi Code: InChI=1S/C25H31N5O8/c31-19(9-5-2-6-12-30-22(34)10-11-23(30)35)26-14-20(32)27-15-21(33)29-18(25(38)28-16-24(36)37)13-17-7-3-1-4-8-17/h1,3-4,7-8,10-11,18H,2,5-6,9,12-16H2,(H,26,31)(H,27,32)(H,28,38)(H,29,33)(H,36,37)/t18-/m0/s1

SMILES Code: O=C(CCCCCN1C(C=CC1=O)=O)NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
In vitro activity: TBD
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 529.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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