WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462747

CAS#: 78263-45-3

Description: Syndyphalin is a synthetic met-enkephalin that increases feed intake in sheep and transiently increases circulating GH concentrations in sheep, rats, and pigs.

Chemical Structure

CAS# 78263-45-3

Theoretical Analysis

MedKoo Cat#: 462747
Name: Syndyphalin
CAS#: 78263-45-3
Chemical Formula: C25H34N4O5S
Exact Mass: 502.225
Molecular Weight: 502.63
Elemental Analysis: C, 59.74; H, 6.82; N, 11.15; O, 15.92; S, 6.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Syndyphalin-33;

IUPAC/Chemical Name: N-(L-tyrosyl)-N-((R)-2-amino-2-(methyl(phenethyl)amino)acetyl)-4-(methylsulfinyl)butanamide


InChi Code: InChI=1S/C25H34N4O5S/c1-28(15-14-18-7-4-3-5-8-18)23(27)25(33)29(22(31)9-6-16-35(2)34)24(32)21(26)17-19-10-12-20(30)13-11-19/h3-5,7-8,10-13,21,23,30H,6,9,14-17,26-27H2,1-2H3/t21-,23+,35?/m0/s1

SMILES Code: CN([C@H](C(N(C([C@H](Cc1ccc(O)cc1)N)=O)C(CCCS(C)=O)=O)=O)N)CCc2ccccc2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 502.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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1: Nakamura H, Kiso Y, Motoyoshi S, Yoshida N, Ishii K, Yokoyama Y, Kadokawa T, Shimizu M. Analgesic and other pharmacological activities of an enkephalin analogue, syndyphalin (SD)-25. Eur J Pharmacol. 1982 Nov 19;85(2):133-42. doi: 10.1016/0014-2999(82)90458-7. PMID: 6891334.

2: Cooper TA, Jenkins SJ, Wojakiewicz L, Kattesh HG, Kojima CJ. Effects of weaning and syndyphalin-33 on expression of melanocortinergic appetite- regulating genes in swine. Domest Anim Endocrinol. 2011 Apr;40(3):165-72. doi: 10.1016/j.domaniend.2010.11.001. Epub 2010 Dec 7. PMID: 21194875.

3: Kojima CJ, Jenkins SJ, Cooper TA, Roberts MP, Carroll JA, Kattesh HG. Effects of syndyphalin-33 on feed intake and circulating measures of growth hormone, cortisol, and immune cell populations in the recently weaned pig. J Anim Sci. 2009 Oct;87(10):3218-25. doi: 10.2527/jas.2009-2033. Epub 2009 Jun 19. PMID: 19542501.

4: Buonomo FC, Tou JS, Kaempfe LA. Stimulation of somatotropin secretion following peripheral administration of the tripeptide, syndyphalin 33 in sheep, pigs and rats. Life Sci. 1991;48(20):1953-61. doi: 10.1016/0024-3205(91)90228-4. PMID: 2023526.

5: Obese FY, Whitlock BK, Steele BP, Buonomo FC, Sartin JL. Long-term feed intake regulation in sheep is mediated by opioid receptors. J Anim Sci. 2007 Jan;85(1):111-7. doi: 10.2527/jas.2006-404. PMID: 17179546.

6: Quirion R, Kiso Y, Pert CB. Syndyphalin SD-25: a highly selective ligand for mu opiate receptors. FEBS Lett. 1982 May 17;141(2):203-6. doi: 10.1016/0014-5793(82)80047-1. PMID: 6284554.

7: Kiso Y, Miyazaki T, Akita T, Moritoki H, Takei M, Nakamura H. Syndyphalin-33, a synthetic tripeptide alkylamide with prolonged analgesic activity. FEBS Lett. 1981 Dec 21;136(1):101-4. doi: 10.1016/0014-5793(81)81223-9. PMID: 7319054.

8: Kiso Y, Miyazaki T, Akita T, Nakamura H. Syndyphalin, an enkephalin-like peptide with prolonged subcutaneous analgesic activity. Eur J Pharmacol. 1981 May 8;71(2-3):347-8. doi: 10.1016/0014-2999(81)90039-x. PMID: 7250195.

9: Henichart JP, Carette B, Bernier JL, Houssin R. Opiate receptor interaction of a new analgesic drug 2-piperidinoethyl dibenzylglycolate. Chem Biol Interact. 1985 Feb-Apr;53(1-2):77-87. doi: 10.1016/s0009-2797(85)80086-7. PMID: 2986861.