Beclamide

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MedKoo CAT#: 535292

CAS#: 501-68-8

Description: Beclamide is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-26. Prices are subject to change without notice.

Beclamide is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 535292
Name: Beclamide
CAS#: 501-68-8
Chemical Formula: C10H12ClNO
Exact Mass: 197.0607
Molecular Weight: 197.662
Elemental Analysis: C, 60.77; H, 6.12; Cl, 17.93; N, 7.09; O, 8.09


Synonym: Beclamide

IUPAC/Chemical Name: N-Benzyl-3-chloropropionamide

InChi Key: JPYQFYIEOUVJDU-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H12ClNO/c11-7-6-10(13)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)

SMILES Code: O=C(NCC1=CC=CC=C1)CCCl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Ahmadi M, Nicholls PJ, Smith HJ, Spencer PS, Preet-Ryatt MS, Spragg BP. Metabolism of beclamide after a single oral dose in man: quantitative studies. J Pharm Pharmacol. 1995 Oct;47(10):876-8. doi: 10.1111/j.2042-7158.1995.tb05757.x. PMID: 8583359.

2: Raptis C, Garcia-Borreguero D, Weber MM, Dose M, Bremer D, Emrich HM. Anticonvulsants as adjuncts for the neuroleptic treatment of schizophrenic psychoses: a clinical study with beclamide. Acta Psychiatr Scand. 1990 Feb;81(2):162-7. doi: 10.1111/j.1600-0447.1990.tb06472.x. PMID: 2183543.

3: Darmani NA, Sewell RD, Nicholls PJ. Acute effects of beclamide on brain regional monoamine concentrations, their metabolites and radioligand binding studies. J Pharm Pharmacol. 1991 Jun;43(6):425-9. doi: 10.1111/j.2042-7158.1991.tb03502.x. PMID: 1717674.

4: WILSON J, WALTON JN, NEWELL DJ. Beclamide in intractable epilepsy: a controlled trial. Br Med J. 1959 May 16;1(5132):1275-8. doi: 10.1136/bmj.1.5132.1275. PMID: 13651708; PMCID: PMC1993459.

5: Ozer AY, Hincal AA. Studies on the masking of unpleasant taste of beclamide: microencapsulation and tabletting. J Microencapsul. 1990 Jul-Sep;7(3):327-39. doi: 10.3109/02652049009021843. PMID: 2384836.

6: Movsisyan M, Heugebaert TSA, Roman BI, Dams R, Van Campenhout R, Conradi M, Stevens CV. Atom- and Mass-economical Continuous Flow Production of 3-Chloropropionyl Chloride and its Subsequent Amidation. Chemistry. 2018 Aug 9;24(45):11779-11784. doi: 10.1002/chem.201802208. Epub 2018 Jul 13. PMID: 29879290.

7: Darmani NA, Sewell RD, Nicholls PJ. Effects of beclamide on isolation-induced aggression and locomotor activity in mice. J Pharm Pharmacol. 1988 Dec;40(12):891-3. doi: 10.1111/j.2042-7158.1988.tb06297.x. PMID: 2907587.

8: Darmani NA, Sewell RD, Hasan MY, Nicholls PJ. Comparison of the inhibitory action of aminobeclamide and beclamide on socially offensive behaviour. J Pharm Pharmacol. 1990 Jun;42(6):447-9. doi: 10.1111/j.2042-7158.1990.tb06591.x. PMID: 1979631.

9: Leach H, Lewis M, Luscombe DK, Nicholls PJ. Studies of plasma levels and the excretion of beclamide in normal human subjects [proceedings]. Br J Clin Pharmacol. 1975 Aug;2(4):377P-378P. PMID: 1234008.

10: Nicholls PJ, Ross MS, Luscombe DK. Metabolism of beclamide, N-benzyl-3-chloropropionamide, in man. Xenobiotica. 1979 Feb;9(2):129-40. doi: 10.3109/00498257909038713. PMID: 433311.

11: Jones OP, Leach H, Luscombe DK, Nicholls PJ. A simple method for the determination of beclamide in plasma by gas chromatography. Br J Clin Pharmacol. 1975 Aug;2(4):364-5. doi: 10.1111/j.1365-2125.1975.tb02788.x. PMID: 1233999; PMCID: PMC1402593.

12: Sawaya MC, Horton RW, Meldrum BS. Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA. Epilepsia. 1975 Nov;16(4):649-55. doi: 10.1111/j.1528-1157.1975.tb04747.x. PMID: 9890792.

13: Rydzynski Z, Kocur J, Czarnecka E. Effets du béclamide sur le comportement des animaux [Effects of beclamide on animal behavior]. Therapie. 1977 May- Jun;32(3):365-74. French. PMID: 563113.

14: Luscombe DK, Nicholls PJ. Proceedings: Potential tolerance to beclamide and related drug interactions. J Pharm Pharmacol. 1975 Dec;27 Suppl?-2:18P. PMID: 2690.

15: Skerritt JH, Johnston GA. Inhibition of amino acid transmitter release from rat brain slices by phenytoin and related anticonvulsants. Clin Exp Pharmacol Physiol. 1983 Sep-Oct;10(5):527-33. doi: 10.1111/j.1440-1681.1983.tb00221.x. PMID: 6139193.

16: Cornelis J, Chaillet F. Détermination simultanée par chromatographie liquide haute performance de huit antiépileptiques et sédatifs dans le plasma. Utilisation d'un système à compression radiale de la colonne [Simultaneous high performance liquid chromatographic determination of 8 anti-epileptics and sedatives in plasma. Use of a radial compression column system]. Ann Biol Clin (Paris). 1984;42(4):295-9. French. PMID: 6497073.

17: KAYE N, JONES IH, WARRIER GK. Nydrane as an anticonvulsant. Br Med J. 1959 Mar 7;1(5122):627-9. doi: 10.1136/bmj.1.5122.627. PMID: 13629072; PMCID: PMC1992701.

18: Darling CM, Pryor P. Anticonvulsant activity of alkyl-substituted N-benzylcyanoacetamides. J Pharm Sci. 1979 Jan;68(1):108-10. doi: 10.1002/jps.2600680137. PMID: 758443.

19: GANIDEL G, MERVEILLE P, QUEVAUVILBER A, THUILLIER J. Traitement de quelques cas d'épilepsie par un nouvel antiépileptique: la-N-benzyl beta chloro propionamide [N-benzyl-3-chloropropionamide, a new anticonvulsant, in therapy of some cases of epilepsy]. Ann Med Psychol (Paris). 1953 Nov;111(2 4):531-6. Undetermined Language. PMID: 13125052.

20: ARTEMENKO GN, KEVERINA NV. [Chloracon--an antiepileptic drug]. Med Prom SSSR. 1961 Dec;12:57. Russian. PMID: 13862637.