5-Methoxycanthinone
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462645

CAS#: 15071-56-4

Description: 5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties. It is cytotoxic to KB, A549, and HCT-8 cells. It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1. However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.


Chemical Structure

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5-Methoxycanthinone
CAS# 15071-56-4

Theoretical Analysis

MedKoo Cat#: 462645
Name: 5-Methoxycanthinone
CAS#: 15071-56-4
Chemical Formula: C15H10N2O2
Exact Mass: 250.0742
Molecular Weight: 250.257
Elemental Analysis: C, 71.99; H, 4.03; N, 11.19; O, 12.79

Price and Availability

Size Price Availability Quantity
1.0mg USD 450.0 2 Weeks
5.0mg USD 1250.0 2 Weeks
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Synonym: 5-Methoxycanthin-6-one; NSC 88929; NSC88929; NSC-88929;

IUPAC/Chemical Name: 5-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one

InChi Key: TXEFUSAHPIYZHD-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10N2O2/c1-19-13-8-11-14-10(6-7-16-11)9-4-2-3-5-12(9)17(14)15(13)18/h2-8H,1H3

SMILES Code: COC1=CC2=NC=CC3=C2N(C1=O)C4=C3C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 250.257 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Xu Z, Chang FR, Wang HK, Kashiwada Y, McPhail AT, Bastow KF, Tachibana Y, Cosentino M, Lee KH. Anti-HIV agents 45(1) and antitumor agents 205.(2) two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana. J Nat Prod. 2000 Dec;63(12):1712-5. doi: 10.1021/np000260u. PMID: 11141127.