WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462645
Description: 5-Methoxycanthinone is an alkaloid that has been found in L. floridana and has anticancer properties. It is cytotoxic to KB, A549, and HCT-8 cells. It is active against the P. falciparum mefloquine-resistant strain F32 and the multidrug and chloroquine-resistant strain K1. However, it increases the parasite load by 68.4% in a mouse model of leishmaniasis when administered at a dose of 10 mg/kg per day.
MedKoo Cat#: 462645
Chemical Formula: C15H10N2O2
Exact Mass: 250.0742
Molecular Weight: 250.257
Elemental Analysis: C, 71.99; H, 4.03; N, 11.19; O, 12.79
Synonym: 5-Methoxycanthin-6-one; NSC 88929; NSC88929; NSC-88929;
IUPAC/Chemical Name: 5-methoxy-6H-indolo[3,2,1-de][1,5]naphthyridin-6-one
InChi Key: TXEFUSAHPIYZHD-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H10N2O2/c1-19-13-8-11-14-10(6-7-16-11)9-4-2-3-5-12(9)17(14)15(13)18/h2-8H,1H3
SMILES Code: COC1=CC2=NC=CC3=C2N(C1=O)C4=C3C=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 250.257 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Xu Z, Chang FR, Wang HK, Kashiwada Y, McPhail AT, Bastow KF, Tachibana Y, Cosentino M, Lee KH. Anti-HIV agents 45(1) and antitumor agents 205.(2) two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana. J Nat Prod. 2000 Dec;63(12):1712-5. doi: 10.1021/np000260u. PMID: 11141127.