Karwinskia toxin T-544

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462639

CAS#: 56678-09-2

Description: Karwinskia toxin T-544 is a neurotoxin isolated from fruits and roots of several Karwinskia species and was resolved into two stereoisomers.

Chemical Structure

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Karwinskia toxin T-544
CAS# 56678-09-2
Instruction

Theoretical Analysis

MedKoo Cat#: 462639
Name: Karwinskia toxin T-544
CAS#: 56678-09-2
Chemical Formula: C32H32O8
Exact Mass: 544.21
Molecular Weight: 544.600
Elemental Analysis: C, 70.58; H, 5.92; O, 23.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: T-544 toxin; Tullidinol;

IUPAC/Chemical Name: 3,8,9-trihydroxy-7-(10-hydroxy-7,9-dimethoxy-1,3-dimethyl-3,4-dihydro-1H-benzo[g]isochromen-5-yl)-3-methyl-3,4-dihydroanthracen-1(2H)-one

InChi Key: OFXNQLFWWFUNRK-UHFFFAOYSA-N

InChi Code: InChI=1S/C32H32O8/c1-14-8-20-24(15(2)40-14)30(35)28-21(10-18(38-4)11-23(28)39-5)27(20)19-7-6-16-9-17-12-32(3,37)13-22(33)25(17)31(36)26(16)29(19)34/h6-7,9-11,14-15,34-37H,8,12-13H2,1-5H3

SMILES Code: COc(cc1OC)cc2c1c(O)c(C(OC(C3)C)C)c3c2c(cc4)c(O)c5c4cc(CC(O)(CC6=O)C)c6c5O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 544.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Garza-Ocañas L, Hsieh GC, Acosta D, Torres-Alanís O, Piñeyro-López A. Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures. Toxicology. 1992;73(3):259-67. doi: 10.1016/0300-483x(92)90068-p. PMID: 1631903.

2: Garza-Ocañas L, Hsieh GC, Acosta D, Torres-Alanís O, Piñeyro-López A. Toxicity assessment of toxins T-514 and T-544 of buckthorn (Karwinskia humboldtiana) in primary skin and liver cell cultures. Toxicology. 1992;73(2):191-201. doi: 10.1016/0300-483x(92)90102-k. PMID: 1609429.

3: Salazar-Aranda R, Sepúlveda-Saavedra J, Waksman de Torres N, Piñeyro-López A, Moreno-Sepúlveda M. Effect of peroxisomicine A2 and T 544 of the genus Karwinskia on peroxisomes of Candida boidinii. FEMS Microbiol Lett. 1998 Jan 15;158(2):255-60. doi: 10.1111/j.1574-6968.1998.tb12829.x. PMID: 9465396.

4: Valadez-Alvizo R, Rodríguez-Alvarado A, Martínez de Villarreal L, González- Alanís R, Piñeyro-López A. Effect of toxins 544 and 514 from Karwinskia humboldtiana (buckthorn) plant upon fetal development of the mouse. Toxicon. 1993 Oct;31(10):1329-32. doi: 10.1016/0041-0101(93)90406-9. PMID: 8303727.

5: Waksman N, Benavides-Cortez G, Rivas-Galindo V. Biologically active anthracenones from roots of Karwinskia parvifolia. Phytochemistry. 1999 Mar;50(6):1041-6. doi: 10.1016/s0031-9422(98)00587-1. PMID: 10419282.

6: Moreno-Sepúlveda M, Vargas-Zapata R, Ballesteros-Elizondo R, Piñeyro-López A, Sepúlveda-Saavedra J. Studies on the effect of peroxisomicine on catalase activity in albino mice. Toxicon. 1997 May;35(5):777-83. doi: 10.1016/s0041-0101(96)00164-x. PMID: 9203303.

7: Muñoz-Martínez EJ, Cuéllar-Pedroza LH, Rubio-Franchini C, Jáuregui-Rincón J, Joseph-Nathan P. Depression of fast axonal transport in axons demyelinated by intraneural injection of a neurotoxin from K. humboldtiana. Neurochem Res. 1994 Nov;19(11):1341-8. doi: 10.1007/BF00972461. PMID: 7534872.