Befuraline

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MedKoo CAT#: 535286

CAS#: 41717-30-0

Description: Befuraline is a bioactive chemical.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-28. Prices are subject to change without notice.

Befuraline is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 535286
Name: Befuraline
CAS#: 41717-30-0
Chemical Formula: C20H20N2O2
Exact Mass: 320.1525
Molecular Weight: 320.392
Elemental Analysis: C, 74.98; H, 6.29; N, 8.74; O, 9.99


Synonym: Befuraline

IUPAC/Chemical Name: 1-(2-Benzofuranylcarbonyl)-4-benzylpiperazine

InChi Key: SRIJFPBZWUFLFD-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H20N2O2/c23-20(19-14-17-8-4-5-9-18(17)24-19)22-12-10-21(11-13-22)15-16-6-2-1-3-7-16/h1-9,14H,10-13,15H2

SMILES Code: O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC4=CC=CC=C4O3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Boksay IJ, Popendiker K, Weber RO, Söder A. Synthesis and pharmacological activity of befuraline (N-benzo[b]furan-2-ylcarbonyl-N'-benzylpiperazine), a new antidepressant compound. Arzneimittelforschung. 1979;29(2):193-204. PMID: 582130.

2: Gastpar M, Gastpar G, Gilsdorf U. Befuraline, its safety and efficacy in depressed inpatients. Pharmacopsychiatry. 1985 Nov;18(6):351-5. doi: 10.1055/s-2007-1017396. PMID: 4089015.

3: Clemens R, Clemens U. Offener Versuch mit Befuraline (DIV 154) bei 64 depressiv Kranken [Open study of befuraline (DIV 154) in 64 depressive patients (author's transl)]. Arzneimittelforschung. 1977;27(12):2416-21. German. PMID: 341906.

4: Valdman AV, Avdulov NA, Rozganets VV, Rusacov DY. Behavioural and neurochemical studies of the action of atypical antidepressants. Acta Physiol Pharmacol Bulg. 1983;9(3):3-10. PMID: 6142583.

5: Younes-El-Hage S, Labssita Y, Baziard-Mouysset G, Payard M, Caignard DH, Rubat C. Synthèse et étude de l'activité antidépressive d'aryl et hétéroaryl carboxamides de la benzylpipérazine [Synthesis and antidepressive activity study of aryl and heteroaryl carboxamides of benzylpiperazine]. Ann Pharm Fr. 2000 Jul;58(4):254-9. French. PMID: 10915973.

6: Rozhanets VV, Rusakov DIu, Val'dman AV. Izuchenie afinnosti razlichnykh antidepressantov k imipraminovym retseptoram sinapticheskikh membran golovnogo mozga myshi [Affinity of various antidepressive agents to imipramine receptors of synaptic membranes in mouse brain]. Biull Eksp Biol Med. 1982 Oct;94(10):42-3. Russian. PMID: 6293607.

7: Avdulov NA, Maĭsov NI. Atipichnye antidepressanty: vliianie na sinaptosomal'nyĭ zakhvat serotonina i GAMK [Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]. Biull Eksp Biol Med. 1981 Nov;92(11):564-6. Russian. PMID: 7198493.

8: Rusakov DIu, Val'dman AV. Primenenie plavatel'nogo testa dlia vyiavleniia antidepressivnoĭ aktivnosti pri odnokratnom i khronicheskom vvedenii veshchestv [Use of the swimming test for demonstrating antidepressive activity of drugs during single and repeated administration]. Farmakol Toksikol. 1983 Sep- Oct;46(5):107-11. Russian. PMID: 6226535.

9: Komarek J, Neumann FJ. The cardiovascular activity of a new antidepressant DIV 154 in comparison with imipramine. Arzneimittelforschung. 1977;27(11):2066-70. PMID: 580001.

10: Avdulov NA, Zaslavskiĭ BIu, Mikheeva LM, Val'dman AV. Sopostavlenie membranotropnosti i otnositel'noĭ gidrofobnosti antidepressantov razlichnykh khimicheskikh grupp [Comparison of membranotropic and relative hydrophobic properties of antidepressants with different chemical structure]. Biull Eksp Biol Med. 1982 Sep;94(9):66-7. Russian. PMID: 7171827.

11: Avdulov NA, Dobretsov GE, Val'dman AV. Korreliatsiia mezhdu srodstovm antidepressantov k membranam i ikh vliianiem na obratnyĭ zakhvat neĭromediatorov [Correlation between antidepressant membrane affinity and their effects on neuromediator reuptake]. Biull Eksp Biol Med. 1981 Aug;92(8):44-6. Russian. PMID: 7295965.