WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462565
CAS#: ZXH-3-26 HCl
Description: ZXH-3-26 is a selective PROTAC BRD4 degrader.
MedKoo Cat#: 462565
Name: ZXH-3-26 HCl
CAS#: ZXH-3-26 HCl
Chemical Formula: C38H38Cl2N8O7S
Exact Mass: 784.2194
Molecular Weight: 821.731
Elemental Analysis: C, 55.54; H, 4.66; Cl, 8.63; N, 13.64; O, 13.63; S, 3.90
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Related CAS #: 2243076-67-5 (free base) 2307475-86-9 (TFA) ZXH-3-26 HCl
Synonym: ZXH-3-26; ZXH3-26; ZXH 3-26; ZXH-326; ZXH326; ZXH 326; ZXH-3-26 HCl; ZXH-3-26 Hydrochloride.
IUPAC/Chemical Name: methyl 2-((6S)-4-(4-chlorophenyl)-2-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)pentyl)carbamoyl)-3,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate hydrochloride
InChi Key: PPIOEVXQEWNZJE-XZTCEYQHSA-N
InChi Code: InChI=1S/C38H37ClN8O7S.ClH/c1-19-29-31(21-10-12-22(39)13-11-21)42-25(18-28(49)54-3)33-45-44-20(2)46(33)38(29)55-32(19)35(51)41-17-6-4-5-16-40-24-9-7-8-23-30(24)37(53)47(36(23)52)26-14-15-27(48)43-34(26)50;/h7-13,25-26,40H,4-6,14-18H2,1-3H3,(H,41,51)(H,43,48,50);1H/t25-,26?;/m0./s1
SMILES Code: O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 821.731 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Nowak RP, DeAngelo SL, Buckley D, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018;14(7):706-714. doi:10.1038/s41589-018-0055-y