BYK-49187
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574606

CAS#: 163120-31-8

Description: BYK-49187 is a PARP-1 and PARP-2 inhibitor that has been shown to reduce myocardial infarct size in vivo.

Chemical Structure

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BYK-49187
CAS# 163120-31-8
Instruction

Theoretical Analysis

MedKoo Cat#: 574606
Name: BYK-49187
CAS#: 163120-31-8
Chemical Formula: C19H21N5O
Exact Mass: 335.17
Molecular Weight: 335.410
Elemental Analysis: C, 68.04; H, 6.31; N, 20.88; O, 4.77

Price and Availability

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1mg USD 270 2 Weeks
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Synonym: BYK 49187; BYK-49187; BYK49187

IUPAC/Chemical Name: 2-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)-4,5-dihydro-6H-imidazo[4,5,1-ij]quinolin-6-one

InChi Key: YKJJROIKVYSPDH-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21N5O/c1-12-17(21-11-20-12)13-5-8-23(9-6-13)19-22-15-4-2-3-14-16(25)7-10-24(19)18(14)15/h2-4,11,13H,5-10H2,1H3,(H,20,21)

SMILES Code: O=C1CCN(C(N2CCC(C3=C(C)N=CN3)CC2)=N4)C5=C4C=CC=C15

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 335.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Eltze et al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587 PMID: 18809672

2. Sunderland et al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049 PMID: 21417348