B2
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MedKoo CAT#: 574605

CAS#: 115687-05-3

Description: B2 is a biochemical that promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. B2 prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.


Chemical Structure

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B2
CAS# 115687-05-3

Theoretical Analysis

MedKoo Cat#: 574605
Name: B2
CAS#: 115687-05-3
Chemical Formula: C20H17ClN4O3
Exact Mass: 396.0989
Molecular Weight: 396.83
Elemental Analysis: C, 60.53; H, 4.32; Cl, 8.93; N, 14.12; O, 12.10

Price and Availability

Size Price Availability Quantity
10.0mg USD 315.0 2 Weeks
50.0mg USD 1000.0 2 Weeks
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Synonym: B2; CPNQ

IUPAC/Chemical Name: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

InChi Key: KLNPVNZJCWIQSK-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H17ClN4O3/c21-15-5-3-14(4-6-15)20(26)24-12-10-23(11-13-24)17-7-8-18(25(27)28)19-16(17)2-1-9-22-19/h1-9H,10-13H2

SMILES Code: O=[N+](C1=C2N=CC=CC2=C(N3CCN(C(C4=CC=C(Cl)C=C4)=O)CC3)C=C1)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 396.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Bodner et al (2006) Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases. Proc.Natl.Acad.Sci.USA 103 4246

B2

10.0mg / USD 315.0