WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462537
CAS#: 13860-66-7
Description: N3PT is a potent and selective transketolase(TK) inhibitor both in vitro and in vivo.
MedKoo Cat#: 462537
Name: N3PT
CAS#: 13860-66-7
Chemical Formula: C13H19Cl2N3OS
Exact Mass: 335.0626
Molecular Weight: 336.275
Elemental Analysis: , 46.43; H, 5.70; Cl, 21.08; N, 12.50; O, 4.76; S, 9.53
This product is not in stock, which may be available by custom synthesis.
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Synonym: N3PT; N3-pyridyl thiamine
IUPAC/Chemical Name: 3-((2-amino-6-methylpyridin-3-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride
InChi Key: ZLGKCAQWOASSTP-UHFFFAOYSA-M
InChi Code: InChI=1S/C13H18N3OS.2ClH/c1-9-3-4-11(13(14)15-9)7-16-8-18-12(5-6-17)10(16)2;;/h3-4,8,17H,5-7H2,1-2H3,(H2,14,15);2*1H/q+1;;/p-1
SMILES Code: CC1=C(CCO)SC=[N+]1CC2=CC=C(C)N=C2N.[H]Cl.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 336.275 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Allen A. Thomas, Josh Ballard, Bryan Bernat. Potent and Selective Thiamine Antagonists That Inhibit Transketolase.
2: Jeno Gyuris, May Han, Ronan C, N3-pyridyl-thiamine and its use in cancer treatments. Patent Numeber: WO2005094803 A2
3: Thomas AA, De Meese J, Le Huerou Y, et al. Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett. 2008;18(2):509-512. doi:10.1016/j.bmcl.2007.11.098
