Vps34-IN-2
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MedKoo CAT#: 462532

CAS#: 1523404-29-6

Description: Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34.


Chemical Structure

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Vps34-IN-2
CAS# 1523404-29-6

Theoretical Analysis

MedKoo Cat#: 462532
Name: Vps34-IN-2
CAS#: 1523404-29-6
Chemical Formula: C18H25F3N4O3
Exact Mass: 402.1879
Molecular Weight: 402.4182
Elemental Analysis: C, 53.72; H, 6.26; F, 14.16; N, 13.92; O, 11.93

Price and Availability

Size Price Availability Quantity
1.0mg USD 410.0 2 Weeks
5.0mg USD 1000.0 2 Weeks
10.0mg USD 1510.0 2 Weeks
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Synonym: Vps34-IN-2; Vps34-IN 2; Vps34 IN-2; Vps34 IN 2

IUPAC/Chemical Name: (S)-9-(3-methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

InChi Key: ITCIAOUZMPREOO-OCCSQVGLSA-N

InChi Code: InChI=1S/C18H25F3N4O3/c1-11(2)13(26)9-25-14(18(19,20)21)4-5-24-16(27)8-15(22-17(24)25)23-6-7-28-10-12(23)3/h8,11-12,14H,4-7,9-10H2,1-3H3/t12-,14+/m1/s1

SMILES Code: O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC(C(C)C)=O)[C@H](C(F)(F)F)CCN31

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 402.4182 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Pasquier B, El-Ahmad Y, Filoche-Rommé B, et al. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. J Med Chem. 2015;58(1):376-400. doi:10.1021/jm5013352