BAY-1251152 racemate

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MedKoo CAT#: 207142

CAS#: 1610358-53-6 (racemate)

Description: BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.

Chemical Structure

BAY-1251152 racemate
CAS# 1610358-53-6 (racemate)

Theoretical Analysis

MedKoo Cat#: 207142
Name: BAY-1251152 racemate
CAS#: 1610358-53-6 (racemate)
Chemical Formula: C19H18F2N4O2S
Exact Mass: 404.1119
Molecular Weight: 404.4358
Elemental Analysis: C, 56.43; H, 4.49; F, 9.40; N, 13.85; O, 7.91; S, 7.93

Price and Availability

Size Price Availability Quantity
25.0mg USD 250.0 2 Weeks
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2850.0 2 Weeks
1.0g USD 4250.0 2 Weeks
2.0g USD 7250.0 2 Weeks
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Related CAS #: 1610358-53-6 (racemate)   1610358-56-9 (rotation +)   1610358-59-2 (roation -)   1610408-96-2 (R-isomer)   1610408-97-3 (S-isomer)   1610368-59-6 (R-isomer HCl)   1610368-60-9 (S-isomer HCl)    

Synonym: BAY-1251152 racemate; (±)-BAY-1251152; BAY 1251152; BAY1251152;

IUPAC/Chemical Name: ((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone


InChi Code: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)

SMILES Code: N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 50.0 123.63

Preparing Stock Solutions

The following data is based on the product molecular weight 404.4358 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information

The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.