BAY-1251152 racemate
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MedKoo CAT#: 207142

CAS#: 1610358-53-6 (racemate)

Description: BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.


Chemical Structure

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BAY-1251152 racemate
CAS# 1610358-53-6 (racemate)

Theoretical Analysis

MedKoo Cat#: 207142
Name: BAY-1251152 racemate
CAS#: 1610358-53-6 (racemate)
Chemical Formula: C19H18F2N4O2S
Exact Mass: 404.11
Molecular Weight: 404.436
Elemental Analysis: C, 56.43; H, 4.49; F, 9.40; N, 13.85; O, 7.91; S, 7.93

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2850 2 Weeks
1g USD 4250 2 Weeks
2g USD 7250 2 Weeks
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Related CAS #: 1610358-53-6 (racemate)   1610358-56-9 (rotation +)   1610358-59-2 (roation -)   1610408-96-2 (R-isomer)   1610408-97-3 (S-isomer)   1610368-59-6 (R-isomer HCl)   1610368-60-9 (S-isomer HCl)    

Synonym: BAY-1251152 racemate; (±)-BAY-1251152; BAY 1251152; BAY1251152;

IUPAC/Chemical Name: ((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

InChi Key: YZCUMZWULWOUMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)

SMILES Code: N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.0 123.63

Preparing Stock Solutions

The following data is based on the product molecular weight 404.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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