BAY-1251152 racemate
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MedKoo CAT#: 207142

CAS#: 1610358-53-6 (racemate)

Description: BAY-1251152 racemate, also known as (±)-BAY-1251152, is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. This may cause cell cycle arrest and induce apoptosis, which may lead to a reduction in tumor cell proliferation.


Price and Availability

Size Price Shipping out time Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2150 2 Weeks
1g USD 3550 2 Weeks
2g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-30. Prices are subject to change without notice.

BAY-1251152 racemate is in stock


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 207142
Name: BAY-1251152 racemate
CAS#: 1610358-53-6 (racemate)
Chemical Formula: C19H18F2N4O2S
Exact Mass: 404.1119
Molecular Weight: 404.4358
Elemental Analysis: C, 56.43; H, 4.49; F, 9.40; N, 13.85; O, 7.91; S, 7.93


Related CAS #: 1610358-53-6 (racemate)   1610358-56-9 (rotation +)   1610358-59-2 (roation -)   1610408-96-2 (R-isomer)   1610408-97-3 (S-isomer)   1610368-59-6 (R-isomer HCl)   1610368-60-9 (S-isomer HCl)    

Synonym: BAY-1251152 racemate; (±)-BAY-1251152; BAY 1251152; BAY1251152;

IUPAC/Chemical Name: ((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone

InChi Key: YZCUMZWULWOUMD-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)

SMILES Code: N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

The protein complex PTEF-b, a heterodimer consisting of CDK9 and a regulatory cyclin subunit of the T family, is over-activated in various tumor cell types; it plays a key role in the regulation of Pol II-mediated transcription of anti-apoptotic proteins. Tumor cells are dependent on anti-apoptotic proteins for their survival.