WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462514
CAS#: 1681017-83-3
Description: Venadaparib, also known as IDX-1197, is a potent, selective and orally active PARP inhibitor with IC50s of 1 ~2 nM.. By inhibiting PARP, IDX-1197 stops cancer cells from repairing SSBs and drives the conversion of SSBs into double-strand breaks. IDX-1197 triggers a phenomenon known as synthetic lethality, which is defined by cell death resulting from the simultaneous perturbation of two genes without damaging normal cells. IDX-1197 is primarily aimed at treating homologous recombination deficient (HRD) patients. Notably, IDX-1197 has a particularly strong trapping effect, meaning it is more effective at trapping PARP1 and PARP2 enzymes on damaged DNA.
MedKoo Cat#: 462514
Name: Venadaparib
CAS#: 1681017-83-3
Chemical Formula: C23H23FN4O2
Exact Mass: 406.1805
Molecular Weight: 406.4614
Elemental Analysis: C, 67.97; H, 5.70; F, 4.67; N, 13.78; O, 7.87
Synonym: Venadaparib; IDX-1197; IDX 1197; IDX1197;
IUPAC/Chemical Name: 34-fluoro-7-aza-1(1)-phthalazina-5(1,3)-azetidina-3(1,3)-benzena-8(1)-cyclopropanaoctaphane-14(13H),4-dione
InChi Key: YNBQAYKYNYRCCA-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H23FN4O2/c24-20-8-5-14(10-21-17-3-1-2-4-18(17)22(29)27-26-21)9-19(20)23(30)28-12-15(13-28)11-25-16-6-7-16/h1-5,8-9,15-16,25H,6-7,10-13H2,(H,27,29)
SMILES Code: FC1=C(C(N2CC(CNC3CC3)C2)=O)C=C(C=C1)CC4=NNC(C5=C4C=CC=C5)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 406.4614 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: WHO Drug Information, Vol. 34, No. 2, 2020
