Belinostat Glucuronide
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MedKoo CAT#: 574584

CAS#: 1486471-13-9

Description: Belinostat Glucuronide is the major metabolite of Belinostat. Belinostat is a novel histone deacetylase 3 selective inhibitor that protects β cells from cytokine-induced apoptosis.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 335 2 Weeks
5mg USD 925 2 Weeks
10mg USD 1680 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

Belinostat Glucuronide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 574584
Name: Belinostat Glucuronide
CAS#: 1486471-13-9
Chemical Formula: C21H22N2O10S
Exact Mass: 494.0995
Molecular Weight: 494.47
Elemental Analysis: C, 51.01; H, 4.48; N, 5.67; O, 32.36; S, 6.48


Synonym: Belinostat Glucuronide

IUPAC/Chemical Name: (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(((E)-3-(3-(N-phenylsulfamoyl)phenyl)acrylamido)oxy)tetrahydro-2H-pyran-2-carboxylic Acid

InChi Key: FZFPHALYAMPZAH-UAHLBMKISA-N

InChi Code: InChI=1S/C21H22N2O10S/c24-15(22-33-21-18(27)16(25)17(26)19(32-21)20(28)29)10-9-12-5-4-8-14(11-12)34(30,31)23-13-6-2-1-3-7-13/h1-11,16-19,21,23,25-27H,(H,22,24)(H,28,29)/b10-9+/t16-,17-,18+,19-,21-/m0/s1

SMILES Code: O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](ONC(/C=C/C2=CC=CC(S(=O)(NC3=CC=CC=C3)=O)=C2)=O)O1)O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Dong D, Zhang T, Lu D, Liu J, Wu B. In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes. Xenobiotica. 2017;47(4):277-283. doi:10.1080/00498254.2016.1183061

2. Wang LZ, Ramírez J, Yeo W, et al. Glucuronidation by UGT1A1 is the dominant pathway of the metabolic disposition of belinostat in liver cancer patients [published correction appears in PLoS One. 2014;9(1). doi:10.1371/annotation/df796504-a2ea-4807-a412-85985bb2550b]. PLoS One. 2013;8(1):e54522. doi:10.1371/journal.pone.0054522