BAI1
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574581

CAS#: 329349-20-4

Description: BAI1 is an allosteric inhibitor of Bax channel activation. It binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation. It also selectively inhibits Bax-dependent apoptosis and is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.


Chemical Structure

img
BAI1
CAS# 329349-20-4

Theoretical Analysis

MedKoo Cat#: 574581
Name: BAI1
CAS#: 329349-20-4
Chemical Formula: C19H23Br2Cl2N3O
Exact Mass: 536.9585
Molecular Weight: 540.12
Elemental Analysis: C, 42.25; H, 4.29; Br, 29.59; Cl, 13.13; N, 7.78; O, 2.96

Price and Availability

Size Price Availability Quantity
10.0mg USD 270.0 2 Weeks
50.0mg USD 1245.0 2 Weeks
Bulk inquiry

Synonym: BAI1, BAI 1, BAI-1, Bax channel blocker

IUPAC/Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

InChi Key: HWFKCAFKXZFOQT-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H

SMILES Code: OC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 540.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1. Zhu D, Osuka S, Zhang Z, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation. Cancer Cell. 2018;33(6):1004-1016.e5. doi:10.1016/j.ccell.2018.05.006

2. Tu YK, Duman JG, Tolias KF. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018;38(39):8388-8406. doi:10.1523/JNEUROSCI.3461-17.2018

BAI1

10.0mg / USD 270.0