WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574581

CAS#: 329349-20-4

Description: BAI1 is an allosteric inhibitor of Bax channel activation. It binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation. It also selectively inhibits Bax-dependent apoptosis and is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release.

Chemical Structure

CAS# 329349-20-4

Theoretical Analysis

MedKoo Cat#: 574581
Name: BAI1
CAS#: 329349-20-4
Chemical Formula: C19H23Br2Cl2N3O
Exact Mass: 536.9585
Molecular Weight: 540.12
Elemental Analysis: C, 42.25; H, 4.29; Br, 29.59; Cl, 13.13; N, 7.78; O, 2.96

Price and Availability

Size Price Availability Quantity
10.0mg USD 270.0 2 Weeks
50.0mg USD 1245.0 2 Weeks
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Synonym: BAI1, BAI 1, BAI-1, Bax channel blocker

IUPAC/Chemical Name: 3,6-Dibromo-α-(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride


InChi Code: InChI=1S/C19H21Br2N3O.2ClH/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23;;/h1-4,9-10,15,22,25H,5-8,11-12H2;2*1H

SMILES Code: OC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 540.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Zhu D, Osuka S, Zhang Z, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation. Cancer Cell. 2018;33(6):1004-1016.e5. doi:10.1016/j.ccell.2018.05.006

2. Tu YK, Duman JG, Tolias KF. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018;38(39):8388-8406. doi:10.1523/JNEUROSCI.3461-17.2018


10.0mg / USD 270.0