WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462495
Description: ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET.
MedKoo Cat#: 462495
Name: ICI 89406
Chemical Formula: C19H22N4O3
Exact Mass: 354.1692
Molecular Weight: 354.41
Elemental Analysis: C, 64.39; H, 6.26; N, 15.81; O, 13.54
This product is not in stock, which may be available by custom synthesis.
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Synonym: ICI 89406; ICI-89406; ICI89406
IUPAC/Chemical Name: 1-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-3-phenylurea
InChi Key: HTLWRKRZKFAAAH-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H22N4O3/c20-12-15-6-4-5-9-18(15)26-14-17(24)13-21-10-11-22-19(25)23-16-7-2-1-3-8-16/h1-9,17,21,24H,10-11,13-14H2,(H2,22,23,25)
SMILES Code: O=C(NC1=CC=CC=C1)NCCNCC(O)COC2=CC=CC=C2C#N
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 354.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Law MP, Wagner S, Kopka K, Pike VW, Schober O, Schäfers M. Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET?. Eur J Nucl Med Mol Imaging. 2008;35(1):174-185. doi:10.1007/s00259-007-0553-8
2: Costall B, Naylor RJ. Changes in dopamine receptor status after denervation or chronic receptor stimulation [proceedings]. Br J Pharmacol. 1979;66(3):492P-493P.