Z-YVAD-FMK
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462491

CAS#: 210344-97-1

Description: Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities.

Chemical Structure

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Z-YVAD-FMK
CAS# 210344-97-1
Instruction

Theoretical Analysis

MedKoo Cat#: 462491
Name: Z-YVAD-FMK
CAS#: 210344-97-1
Chemical Formula: C31H39FN4O9
Exact Mass: 630.27
Molecular Weight: 630.670
Elemental Analysis: C, 59.04; H, 6.23; F, 3.01; N, 8.88; O, 22.83

Price and Availability

Size Price Availability Quantity
1mg USD 400 2 Weeks
5mg USD 790 2 Weeks
10mg USD 1270 2 Weeks
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Synonym: Z-YVAD-FMK; Z YVAD FMK; Z YVAD-FMK; Z-YVAD FMK

IUPAC/Chemical Name: Z-Tyr-Val-Ala-Asp-FMK

InChi Key: MVPQJUFFTWWKBT-LBDWYMBGSA-N

InChi Code: InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24-,27-/m0/s1

SMILES Code: O=C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C)=O)=O)OCC2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 630.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li H, Nookala S, Re F. Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J Immunol. 2007;178(8):5271-5276. doi:10.4049/jimmunol.178.8.5271

2: Avivi-Green C, Polak-Charcon S, Madar Z, Schwartz B. Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002;132(7):1812-1818. doi:10.1093/jn/132.7.1812

3: Equils O, Moffatt-Blue C, Ishikawa TO, Simmons CF, Ilievski V, Hirsch E. Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect Dis Obstet Gynecol. 2009;2009:749432. doi:10.1155/2009/749432

4: Künstle G, Leist M, Uhlig S, et al. ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha. Immunol Lett. 1997;55(1):5-10. doi:10.1016/s0165-2478(96)02642-9