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MedKoo CAT#: 555824

CAS#: 1093070-14-4

Description: KOM70144, also known as PLpro inhibitor, is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 µM. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 µM and an EC50 of 21.0 µM. KOM70144 has CAS#1093070-14-4, no formal name For the convenience of scientific communication, we named it as KOM70144 (combined from Inchi key plus CAS#) according to Hodoodo Chemical Nomenclature (https://hodoodo.com/hodoodo-chemical-nomenclature). KOM70144 was first reported by Kiira Ratia et al, Proc Natl Acad Sci U S A. 2008;105(42):16119-16124. (compound 6)

Price and Availability

Size Price Shipping out time Quantity
10mg USD 160 Same day
25mg USD 350 Same day
50mg USD 550 Same day
100mg USD 950 Same day
200mg USD 1650 Same day
500mg USD 2650 Same day
1g USD 3650 2 Weeks
2g USD 5950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-30. Prices are subject to change without notice.

KOM70144 is in stock. The same day shipping after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555824
Name: KOM70144
CAS#: 1093070-14-4
Chemical Formula: C22H22N2O2
Exact Mass: 346.1681
Molecular Weight: 346.43
Elemental Analysis: C, 76.28; H, 6.40; N, 8.09; O, 9.24

Synonym: PLpro inhibitor, KOM70144; KOM-70144; KOM 70144;

IUPAC/Chemical Name: (R)-5-acetamido-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide


InChi Code: InChI=1S/C22H22N2O2/c1-14-11-12-18(24-16(3)25)13-21(14)22(26)23-15(2)19-10-6-8-17-7-4-5-9-20(17)19/h4-13,15H,1-3H3,(H,23,26)(H,24,25)/t15-/m1/s1

SMILES Code: O=C(C1=CC(NC(C)=O)=CC=C1C)N[C@H](C)C2=C(C=CC=C3)C3=CC=C2

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1. Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-​CoV-​2 Papain-​Like Protease
Quick View Other Sources. By Freitas, Brendan T.; Durie, Ian A.; Murray, Jackelyn; Longo, Jaron E.; Miller, Holden C.; Crich, David; Hogan, Robert Jeff; Tripp, Ralph A.; Pegan, Scott D. From ACS Infectious Diseases (2020), Ahead of Print. |

2. Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators. By Buhrlage, Sara; Weisberg, Ellen. From PCT Int. Appl. (2018), WO 2018057618 A1.

3. Compounds and methods for treating respiratory diseases. Ghosh, Arun K.; Takayama, Jun; Mesecar, Andrew David; Johnson, Michael E.; Ratia, Kiira M.; Chaudhuri, Rima; Mulhearn, Debbie C. From U.S. Pat. Appl. Publ. (2011), US 20110269834 A1.

4. Compounds and methods for treating respiratory diseases . By Ghosh, Arun K.; Takayama, Jun. From PCT Int. Appl. (2010), WO 2010022355 A1 20100225.

5. Ratia K, Pegan S, Takayama J, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008;105(42):16119-16124.