Benzovindiflupyr
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 535152

CAS#: 1072957-71-1

Description: Benzovindiflupyr is a fungicide. It inhibits mitochondrial complex II, also known as succinate dehydrogenase (SDH; IC50 = 5.2 nM), and mycelial growth of S. sclerotiorum (EC50 = 0.011 µg/ml). Benzovindiflupyr (60 µg/ml) completely protects eggplant leaves from S. sclerotiorum infection. Formulations containing benzovindiflupyr have been used to control various fungal diseases in agriculture.


Chemical Structure

img
Benzovindiflupyr
CAS# 1072957-71-1

Theoretical Analysis

MedKoo Cat#: 535152
Name: Benzovindiflupyr
CAS#: 1072957-71-1
Chemical Formula: C18H15Cl2F2N3O
Exact Mass: 397.06
Molecular Weight: 398.235
Elemental Analysis: C, 54.29; H, 3.80; Cl, 17.80; F, 9.54; N, 10.55; O, 4.02

Price and Availability

Size Price Availability Quantity
1mg USD 580 2 Weeks
Bulk inquiry

Synonym: Benzovindiflupyr;

IUPAC/Chemical Name: N-(9-(Dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazol-4-carboxamide

InChi Key: CCCGEKHKTPTUHJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H15Cl2F2N3O/c1-25-7-11(15(24-25)17(21)22)18(26)23-12-4-2-3-8-9-5-6-10(13(8)12)14(9)16(19)20/h2-4,7,9-10,17H,5-6H2,1H3,(H,23,26)

SMILES Code: O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC3=C2C4CCC3/C4=C(Cl)\Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 398.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: EFSA (European Food Safety Authority), Bellisai G, Bernasconi G, Brancato A, Carrasco Cabrera L, Ferreira L, Giner G, Greco L, Jarrah S, Kazocina A, Leuschner R, Magrans JO, Miron I, Nave S, Pedersen R, Reich H, Ruocco S, Santos M, Scarlato AP, Theobald A, Vagenende B, Verani A. Modification of the existing maximum residue levels for benzovindiflupyr in leeks and spring onions/green onions/Welsh onions. EFSA J. 2021 Jul 27;19(7):e06774. doi: 10.2903/j.efsa.2021.6774. PMID: 34335923; PMCID: PMC8314168.

2: He F, Wan J, Li X, Chu S, Sun N, Liu R. Toxic effects of benzovindiflupyr, a new SDHI-type fungicide on earthworms (Eisenia fetida). Environ Sci Pollut Res Int. 2021 Jul 2. doi: 10.1007/s11356-021-15207-4. Epub ahead of print. PMID: 34215985.

3: Schmolke A, Bartell SM, Roy C, Desmarteau D, Moore A, Cox MJ, Maples-Reynolds NL, Galic N, Brain R. Applying a Hybrid Modeling Approach to Evaluate Potential Pesticide Effects and Mitigation Effectiveness for an Endangered Fish in Simulated Oxbow Habitats. Environ Toxicol Chem. 2021 Jun 25. doi: 10.1002/etc.5144. Epub ahead of print. PMID: 34171144.

4: Ayer K, Strickland D, Choi MW, Cox K. Optimizing the integration of a biopesticide (Bacillus subtilis QST 713) with a single-site fungicide (benzovindiflupyr) to reduce reliance on synthetic multi-site fungicides (captan and mancozeb) for management of apple scab. Plant Dis. 2021 Jun 18. doi: 10.1094/PDIS-02-21-0426-RE. Epub ahead of print. PMID: 34142850.

5: Yao C, Meyer KG, Gallup C, Bowling AJ, Hufnagl A, Myung K, Lutz J, Slanec T, Pence HE, Delgado J, Wang NX. Florylpicoxamid, a new picolinamide fungicide with broad spectrum activity. Pest Manag Sci. 2021 May 19. doi: 10.1002/ps.6483. Epub ahead of print. PMID: 34010509.

6: Mello FE, Mathioni SM, Fantin LH, Rosa DD, Antunes RFD, Filho NRC, Duvaresch DL, Canteri MG. Sensitivity assessment and SDHC-I86F mutation frequency of Phakopsora pachyrhizi populations to benzovindiflupyr and fluxapyroxad fungicides from 2015 to 2019 in Brazil. Pest Manag Sci. 2021 May 5. doi: 10.1002/ps.6466. Epub ahead of print. PMID: 33950556.

7: Wei G, Huang MW, Wang WJ, Wu Y, Mei SF, Zhou LM, Mei LC, Zhu XL, Yang GF. Expanding the Chemical Space of Succinate Dehydrogenase Inhibitors via the Carbon-Silicon Switch Strategy. J Agric Food Chem. 2021 Apr 7;69(13):3965-3971. doi: 10.1021/acs.jafc.0c07322. Epub 2021 Mar 28. PMID: 33779164.

8: Cosseboom SD, Hu M. Identification and Characterization of Fungicide Resistance in Botrytis Populations from Small Fruit Fields in the Mid-Atlantic United States. Plant Dis. 2021 Mar 9. doi: 10.1094/PDIS-03-20-0487-RE. Epub ahead of print. PMID: 33719541.

9: Zhu J, Li X, Zhang L, Gao Y, Mu W, Liu F. The bioactivity and efficacy of benzovindiflupyr against Corynespora cassiicola, the causal agent of cucumber Corynespora leaf spot. Plant Dis. 2021 Feb 9. doi: 10.1094/PDIS-11-20-2334-RE. Epub ahead of print. PMID: 33560881.

10: Junqueira VB, Müller C, Rodrigues AA, Amaral TS, Batista PF, Silva AA, Costa AC. Do fungicides affect the physiology, reproductive development and productivity of healthy soybean plants? Pestic Biochem Physiol. 2021 Feb;172:104754. doi: 10.1016/j.pestbp.2020.104754. Epub 2020 Dec 5. PMID: 33518047.

11: Yao X, Qiao Z, Zhang F, Liu X, Du Q, Zhang J, Li X, Jiang X. Effects of a novel fungicide benzovindiflupyr in Eisenia fetida: Evaluation through different levels of biological organization. Environ Pollut. 2021 Feb 15;271:116336. doi: 10.1016/j.envpol.2020.116336. Epub 2020 Dec 21. PMID: 33370611.

12: Blagaia AV, Kondratiuk MV, Omelchuk ST, Pelo IM, Kozak ND. COMPARATIVE HYGIENIC ASSESSMENT OF PESTICIDES BEHAVIOR IN SOIL IN INTENSIVE GRAIN FARMING TECHNOLOGIES. Wiad Lek. 2020;73(10):2175-2180. PMID: 33310943.

13: Hagerty CH, Klein AM, Reardon CL, Kroese DR, Melle CJ, Graber KR, Mundt CC. Baseline and Temporal Changes in Sensitivity of Zymoseptoria tritici Isolates to Benzovindiflupyr in Oregon, U.S.A., and Cross-Sensitivity to Other SDHI Fungicides. Plant Dis. 2021 Jan;105(1):169-174. doi: 10.1094/PDIS-10-19-2125-RE. Epub 2020 Nov 10. PMID: 33170771.

14: Gama AB, Cordova LG, Rebello CS, Peres NA. Validation of a Decision Support System for Blueberry Anthracnose and Fungicide Sensitivity of Colletotrichum gloeosporioides Isolates. Plant Dis. 2021 Apr 26:PDIS09201961RE. doi: 10.1094/PDIS-09-20-1961-RE. Epub ahead of print. PMID: 32954983.

15: Oliveira MS, Cordova LG, Peres NA. Efficacy and Baseline Sensitivity of Succinate-Dehydrogenase-Inhibitor Fungicides for Management of Colletotrichum Crown Rot of Strawberry. Plant Dis. 2020 Nov;104(11):2860-2865. doi: 10.1094/PDIS-01-20-0083-RE. Epub 2020 Sep 18. PMID: 32946349.

16: Khodadadi F, González JB, Martin PL, Giroux E, Bilodeau GJ, Peter KA, Doyle VP, Aćimović SG. Identification and characterization of Colletotrichum species causing apple bitter rot in New York and description of C. noveboracense sp. nov. Sci Rep. 2020 Jul 6;10(1):11043. doi: 10.1038/s41598-020-66761-9. Erratum in: Sci Rep. 2020 Nov 24;10(1):20839. PMID: 32632221; PMCID: PMC7338416.

17: He L, Cui K, Song Y, Li T, Liu N, Mu W, Liu F. Activity of the Novel Succinate Dehydrogenase Inhibitor Fungicide Pydiflumetofen Against SDHI- Sensitive and SDHI-Resistant Isolates of Botrytis cinerea and Efficacy Against Gray Mold. Plant Dis. 2020 Aug;104(8):2168-2173. doi: 10.1094/PDIS-12-19-2564-RE. Epub 2020 Jun 11. PMID: 32526154.

18: Gao Y, He L, Zhu J, Cheng J, Li B, Liu F, Mu W. The relationship between features enabling SDHI fungicide binding to the Sc-Sdh complex and its inhibitory activity against Sclerotinia sclerotiorum. Pest Manag Sci. 2020 Aug;76(8):2799-2808. doi: 10.1002/ps.5827. Epub 2020 May 22. PMID: 32216079.

19: Zuniga AI, Oliveira MS, Rebello CS, Peres NA. Baseline Sensitivity of Botrytis cinerea Isolates from Strawberry to Isofetamid Compared to other SDHIs. Plant Dis. 2020 Apr;104(4):1224-1230. doi: 10.1094/PDIS-06-19-1140-RE. Epub 2020 Feb 20. PMID: 32078478.

20: Hou YP, Chen YL, Wu LY, Wang JX, Chen CJ, Zhou MG. Corrigendum to "Baseline sensitivity of Bipolaris maydis to the novel succinate dehydrogenase inhibitor benzovindiflupyr and its efficacy" [Pestic. Biochem. Physiol. 149 (2018) 81-88]. Pestic Biochem Physiol. 2020 Jan;162:122. doi: 10.1016/j.pestbp.2019.11.011. Epub 2019 Nov 28. Erratum for: Pestic Biochem Physiol. 2018 Jul;149:81-88. PMID: 31836047.