WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462455

CAS#: 2194903-42-7

Description: H3B-120 is a highly selective, competitive and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor that has anti-cancer activity.

Chemical Structure

CAS# 2194903-42-7

Theoretical Analysis

MedKoo Cat#: 462455
Name: H3B-120
CAS#: 2194903-42-7
Chemical Formula: C19H24N4O2S
Exact Mass: 372.162
Molecular Weight: 372.487
Elemental Analysis: C, 61.27; H, 6.49; N, 15.04; O, 8.59; S, 8.61

Price and Availability

Size Price Availability Quantity
5.0mg USD 480.0 2 Weeks
10.0mg USD 790.0 2 Weeks
50.0mg USD 1800.0 2 Weeks
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Synonym: H3B-120; H3B 120; H3B120

IUPAC/Chemical Name: N1-benzyl-N1-methyl-N4-(4-methylthiazol-2-yl)piperidine-1,4-dicarboxamide


InChi Code: InChI=1S/C19H24N4O2S/c1-14-13-26-18(20-14)21-17(24)16-8-10-23(11-9-16)19(25)22(2)12-15-6-4-3-5-7-15/h3-7,13,16H,8-12H2,1-2H3,(H,20,21,24)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 372.487 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yao S, Nguyen TV, Rolfe A, et al. Small Molecule Inhibition of CPS1 Activity through an Allosteric Pocket. Cell Chem Biol. 2020;27(3):259-268.e5. doi:10.1016/j.chembiol.2020.01.009


5.0mg / USD 480.0