UC-514321
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462440

CAS#: 299420-83-0

Description: UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity.


Chemical Structure

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UC-514321
CAS# 299420-83-0

Theoretical Analysis

MedKoo Cat#: 462440
Name: UC-514321
CAS#: 299420-83-0
Chemical Formula: C26H35NO5
Exact Mass: 441.2515
Molecular Weight: 441.568
Elemental Analysis: C, 70.72; H, 7.99; N, 3.17; O, 18.12

Price and Availability

Size Price Availability Quantity
5.0mg USD 435.0 2 Weeks
10.0mg USD 745.0 2 Weeks
50.0mg USD 1845.0 2 Weeks
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Synonym: UC-514321; UC514321; UC 514321

IUPAC/Chemical Name: 6-((3,5-di-tert-butyl-4-hydroxyphenyl)(morpholino)methyl)benzo[d][1,3]dioxol-5-ol

InChi Key: XNARHFDDQALZPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H35NO5/c1-25(2,3)18-11-16(12-19(24(18)29)26(4,5)6)23(27-7-9-30-10-8-27)17-13-21-22(14-20(17)28)32-15-31-21/h11-14,23,28-29H,7-10,15H2,1-6H3

SMILES Code: OC1=C(C(C)(C)C)C=C(C(C2=C(O)C=C(OCO3)C3=C2)N4CCOCC4)C=C1C(C)(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 441.568 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jiang X, Hu C, Ferchen K, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia [published correction appears in Nat Commun. 2018 Feb 9;9(1):670]. Nat Commun. 2017;8(1):2099. Published 2017 Dec 13. doi:10.1038/s41467-017-02290-w