WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462417
CAS#: 114248-23-6
Description: 2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine.
MedKoo Cat#: 462417
Name: 2',2'-Difluoro-2'-deoxyuridine
CAS#: 114248-23-6
Chemical Formula: C9H10F2N2O5
Exact Mass: 264.0558
Molecular Weight: 264.1848
Elemental Analysis: C, 40.92; H, 3.82; F, 14.38; N, 10.60; O, 30.28
Synonym: 2',2'-Difluoro-2'-deoxyuridine; dFdU;
IUPAC/Chemical Name: 2′-deoxy-2′,2′-difluoro-uridine
InChi Key: FIRDBEQIJQERSE-QPPQHZFASA-N
InChi Code: InChI=1S/C9H10F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h1-2,4,6-7,14,16H,3H2,(H,12,15,17)/t4-,6-,7-/m1/s1
SMILES Code: O=C(N(C=C1)[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)NC1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 264.1848 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al. New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine. Mol. Cancer Ther. 7(8), 2415-2425 (2008).
2: Pauwels, B., Korst, A.E.C., Lambrechts, H.A.J., et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother. Pharmacol. 58(2), 219-228 (2006).
