WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462417

CAS#: 114248-23-6

Description: 2',2'-Difluoro-2'-deoxyuridine is an active metabolite of the anticancer nucleoside analog gemcitabine.

Chemical Structure

CAS# 114248-23-6

Theoretical Analysis

MedKoo Cat#: 462417
Name: 2',2'-Difluoro-2'-deoxyuridine
CAS#: 114248-23-6
Chemical Formula: C9H10F2N2O5
Exact Mass: 264.0558
Molecular Weight: 264.1848
Elemental Analysis: C, 40.92; H, 3.82; F, 14.38; N, 10.60; O, 30.28

Price and Availability

Size Price Availability Quantity
1.0mg USD 220.0 2 Weeks
5.0mg USD 410.0 2 Weeks
10.0mg USD 665.0 2 Weeks
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Synonym: 2',2'-Difluoro-2'-deoxyuridine; dFdU;

IUPAC/Chemical Name: 2′-deoxy-2′,2′-difluoro-uridine


InChi Code: InChI=1S/C9H10F2N2O5/c10-9(11)6(16)4(3-14)18-7(9)13-2-1-5(15)12-8(13)17/h1-2,4,6-7,14,16H,3H2,(H,12,15,17)/t4-,6-,7-/m1/s1

SMILES Code: O=C(N(C=C1)[C@H]2C(F)(F)[C@H](O)[C@@H](CO)O2)NC1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 264.1848 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Veltkamp, S.A., Pluim, D., van Eijndhoven, M.A.J., et al. New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine. Mol. Cancer Ther. 7(8), 2415-2425 (2008).

2: Pauwels, B., Korst, A.E.C., Lambrechts, H.A.J., et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother. Pharmacol. 58(2), 219-228 (2006).