IZCZ-3
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462415

CAS#: 2223019-53-0

Description: IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.


Chemical Structure

img
IZCZ-3
CAS# 2223019-53-0

Theoretical Analysis

MedKoo Cat#: 462415
Name: IZCZ-3
CAS#: 2223019-53-0
Chemical Formula: C46H49N7O
Exact Mass: 715.40
Molecular Weight: 715.946
Elemental Analysis: C, 77.17; H, 6.90; N, 13.70; O, 2.23

Price and Availability

Size Price Availability Quantity
5mg USD 600 2 Weeks
10mg USD 1080 2 Weeks
Bulk inquiry

Synonym: IZCZ-3; IZCZ3; IZCZ 3

IUPAC/Chemical Name: 9-ethyl-3-(1-(4-methoxyphenyl)-4,5-bis(4-(4-methylpiperazin-1-yl)phenyl)-1H-imidazol-2-yl)-9H-carbazole

InChi Key: SETZGUYDZNTJCI-UHFFFAOYSA-N

InChi Code: InChI=1S/C46H49N7O/c1-5-52-42-9-7-6-8-40(42)41-32-35(14-23-43(41)52)46-47-44(33-10-15-36(16-11-33)50-28-24-48(2)25-29-50)45(53(46)38-19-21-39(54-4)22-20-38)34-12-17-37(18-13-34)51-30-26-49(3)27-31-51/h6-23,32H,5,24-31H2,1-4H3

SMILES Code: COC(C=C1)=CC=C1N2C(C3=CC(C(C=CC=C4)=C4N5CC)=C5C=C3)=NC(C6=CC=C(N7CCN(C)CC7)C=C6)=C2C(C=C8)=CC=C8N9CCN(C)CC9

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 715.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hu MH, Wang YQ, Yu ZY, et al. Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. J Med Chem. 2018;61(6):2447-2459. doi:10.1021/acs.jmedchem.7b01697