WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462407
CAS#: 76455-48-6
Description: 4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. It is a calcium modulator that induces apoptosis in different cells, including HL-60 cells.
MedKoo Cat#: 462407
Name: 4-Bromo A23187
CAS#: 76455-48-6
Chemical Formula: C29H36BrN3O6
Exact Mass: 601.1787
Molecular Weight: 602.526
Elemental Analysis: C, 57.81; H, 6.02; Br, 13.26; N, 6.97; O, 15.93
Synonym: 4-Bromo A23187; 4-Bromo A-23187; 4-Bromo A 23187
IUPAC/Chemical Name: 6-bromo-5-(methylamino)-2-((3,9,11-trimethyl-8-(1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl)-1,7-dioxaspiro[5.5]undecan-2-yl)methyl)benzo[d]oxazole-4-carboxylic acid
InChi Key: LDXQFZZGVTWFCF-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H36BrN3O6/c1-14-8-9-29(16(3)11-15(2)27(39-29)17(4)26(34)19-7-6-10-32-19)38-20(14)13-22-33-25-21(37-22)12-18(30)24(31-5)23(25)28(35)36/h6-7,10,12,14-17,20,27,31-32H,8-9,11,13H2,1-5H3,(H,35,36)
SMILES Code: CC1C2(OC(C(C)CC2)CC3=NC4=C(C=C(Br)C(NC)=C4C(O)=O)O3)OC(C(C)C(C5=CC=CN5)=O)C(C)C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 602.526 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Zhu WH, Loh TT. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995;57(23):2091-2099. doi:10.1016/0024-3205(95)02202-t
