WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462361
CAS#: 2380013-17-0
Description: Nampt-IN-5 is a potent and orally active nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 inhibits CYP3A4 activity.
MedKoo Cat#: 462361
Name: Nampt-IN-5
CAS#: 2380013-17-0
Chemical Formula: C25H25N5O2
Exact Mass: 427.2008
Molecular Weight: 427.508
Elemental Analysis: C, 70.24; H, 5.89; N, 16.38; O, 7.48
This product is not in stock, which may be available by custom synthesis.
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Synonym: Nampt IN 5; Nampt-IN-5; Nampt IN-5;Nampt-IN 5
IUPAC/Chemical Name: N-(4-((2-ethoxy-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-3-(pyridin-3-yl)azetidine-1-carboxamide
InChi Key: JWEBCHOGBDMGBY-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H25N5O2/c1-2-32-25-28-22-7-3-4-8-23(22)30(25)15-18-9-11-21(12-10-18)27-24(31)29-16-20(17-29)19-6-5-13-26-14-19/h3-14,20H,2,15-17H2,1H3,(H,27,31)
SMILES Code: O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 427.508 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Palacios DS, Meredith EL, Kawanami T, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT). ACS Med Chem Lett. 2019;10(11):1524-1529. Published 2019 Oct 10. doi:10.1021/acsmedchemlett.9b00325
