RU-58841
new
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555811

CAS#: 154992-24-2

Description: RU-58841 is a non-steroidal antiandrogen that binds to the androgen receptor. RU 58841 is a Candidate of Choice for the Treatment of Acne, Androgenetic Alopecia and Hirsutism. RU-58841 also induces hair regrowth in the bald frontal scalps of postpubertal stumptailed macaques, a model for male pattern baldness.


Price and Availability

Size Price Shipping out time Quantity
200mg USD 160 2 Weeks
500mg USD 350 2 Weeks
1g USD 550 2 Weeks
2g USD 950 2 Weeks
5g USD 2050 2 Weeks
10g USD 3650 2 Weeks
100g USD 8950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-30. Prices are subject to change without notice.

RU-58841 is in stock


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 555811
Name: RU-58841
CAS#: 154992-24-2
Chemical Formula: C17H18F3N3O3
Exact Mass: 369.13
Molecular Weight: 369.3442
Elemental Analysis: C, 55.28; H, 4.91; F, 15.43; N, 11.38; O, 13.00


Synonym: RU-58841; RU 58841; RU58841;

IUPAC/Chemical Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile

InChi Key: ARBYGDBJECGMGA-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3

SMILES Code: N#CC1=CC=C(N(C(N(CCCCO)C2(C)C)=O)C2=O)C=C1C(F)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Castro GA, Ferreira LA. Novel vesicular and particulate drug delivery systems for topical treatment of acne. Expert Opin Drug Deliv. 2008 Jun;5(6):665-79. doi: 10.1517/17425247.5.6.665. PMID: 18532922.

2: Blaschke T, Kankate L, Kramer KD. Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy. Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. doi: 10.1016/j.addr.2007.04.003. Epub 2007 May 3. PMID: 17573146.

3: Stecová J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, Seltmann H, Korting HC, Kramer KD, Schäfer-Korting M. Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: particle characterisation and skin uptake. Pharm Res. 2007 May;24(5):991-1000. doi: 10.1007/s11095-006-9225-9. Epub 2007 Mar 20. PMID: 17372681.

4: Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Schäfer-Korting M. RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia. Pharmazie. 2005 Jan;60(1):8-12. PMID: 15700772.

5: Van Dort ME, Jung YW. Synthesis and structure-activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5285-8. doi: 10.1016/j.bmcl.2004.08.031. PMID: 15454212.

6: Van Dort ME, Jung YW. Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1045-7. doi: 10.1016/s0960-894x(01)00146-9. PMID: 11327585.

7: Pan HJ, Wilding G, Uno H, Inui S, Goldsmith L, Messing E, Chang C. Evaluation of RU58841 as an anti-androgen in prostate PC3 cells and a topical anti-alopecia agent in the bald scalp of stumptailed macaques. Endocrine. 1998 Aug;9(1):39-43. doi: 10.1385/ENDO:9:1:39. PMID: 9798729.

8: Miyamoto H, Yeh S, Wilding G, Chang C. Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7379-84. doi: 10.1073/pnas.95.13.7379. PMID: 9636157; PMCID: PMC22623.

9: De Brouwer B, Tételin C, Leroy T, Bonfils A, Van Neste D. A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice. Br J Dermatol. 1997 Nov;137(5):699-702. PMID: 9415227.

10: Bernard E, Dubois JL, Wepierre J. Importance of sebaceous glands in cutaneous penetration of an antiandrogen: target effect of liposomes. J Pharm Sci. 1997 May;86(5):573-8. doi: 10.1021/js960394l. PMID: 9145381.

11: Obana N, Chang C, Uno H. Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology. 1997 Jan;138(1):356-61. doi: 10.1210/endo.138.1.4890. PMID: 8977424.

12: Matias JR, Gaillard M. Local inhibition of sebaceous gland growth by topically applied RU 58841. Ann N Y Acad Sci. 1995 Jun 12;761:56-65. doi: 10.1111/j.1749-6632.1995.tb31369.x. PMID: 7625751.

13: Cousty-Berlin D, Bergaud B, Bruyant MC, Battmann T, Branche C, Philibert D. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: relation of their systemic activity to the formation of a common metabolite. J Steroid Biochem Mol Biol. 1994 Oct;51(1-2):47-55. doi: 10.1016/0960-0760(94)90114-7. PMID: 7947350.

14: Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D. RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60. doi: 10.1016/0960-0760(94)90250-x. PMID: 8136306.