WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462268
Description: ZEN-3862 is a BET inhibitor and can be used to form PROTACs to induce degradation of BRD4.
MedKoo Cat#: 462268
Chemical Formula: C19H17FN2O3
Exact Mass: 340.1223
Molecular Weight: 340.3544
Elemental Analysis: C, 67.05; H, 5.03; F, 5.58; N, 8.23; O, 14.10
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: ZEN-3862; ZEN3862; ZEN 3862
IUPAC/Chemical Name: 5-(3,5-dimethylisoxazol-4-yl)-1-(3-fluoro-4-(oxiran-2-yl)benzyl)pyridin-2(1H)-one
InChi Key: VQHDSZCBMWYGEK-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17FN2O3/c1-11-19(12(2)25-21-11)14-4-6-18(23)22(9-14)8-13-3-5-15(16(20)7-13)17-10-24-17/h3-7,9,17H,8,10H2,1-2H3
SMILES Code: FC1=C(C2OC2)C=CC(CN3C(C=CC(C4=C(C)ON=C4C)=C3)=O)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 340.3544 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kharenko OA, Patel RG, Brown SD, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018;61(18):8202-8211. doi:10.1021/acs.jmedchem.8b00666