WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574442

CAS#: 909725-61-7

Description: W146 is a sphingosine-1-phosphate (S1P1) antagonist that enhances capillary leakage and restores lymphocyte egress in vivo.

Chemical Structure

CAS# 909725-61-7

Theoretical Analysis

MedKoo Cat#: 574442
Name: W146
CAS#: 909725-61-7
Chemical Formula: C16H27N2O4P
Exact Mass: 342.1708
Molecular Weight: 342.37
Elemental Analysis: C, 56.13; H, 7.95; N, 8.18; O, 18.69; P, 9.05

Price and Availability

Size Price Availability Quantity
1.0mg USD 350.0 2 Weeks
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Synonym: W-146, ML-056

IUPAC/Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid


InChi Code: InChI=1S/C16H27N2O4P/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22)/t15-/m1/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 342.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954

2. Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635


1.0mg / USD 350.0