WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574442
Description: W146 is a sphingosine-1-phosphate (S1P1) antagonist that enhances capillary leakage and restores lymphocyte egress in vivo.
MedKoo Cat#: 574442
Chemical Formula: C16H27N2O4P
Exact Mass: 342.1708
Molecular Weight: 342.37
Elemental Analysis: C, 56.13; H, 7.95; N, 8.18; O, 18.69; P, 9.05
Synonym: W-146, ML-056
IUPAC/Chemical Name: [(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
InChi Key: FWJRVGZWNDOOFH-OAHLLOKOSA-N
InChi Code: InChI=1S/C16H27N2O4P/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22)/t15-/m1/s1
SMILES Code: O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 342.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Sanna et al (2006) Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.Chem.Biol. 8 434 PMID: 16829954
2. Gonzalez-Cabrera et al (2008) Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 74 1308 PMID: 18708635