VUF-5681 dihydrobromide
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574437

CAS#: 639089-06-8

Description: VUF-5681 dihydrobromide is a histamine H3 receptor silent antagonist.

Chemical Structure

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VUF-5681 dihydrobromide
CAS# 639089-06-8
Instruction

Theoretical Analysis

MedKoo Cat#: 574437
Name: VUF-5681 dihydrobromide
CAS#: 639089-06-8
Chemical Formula: C11H21Br2N3
Exact Mass: 353.01
Molecular Weight: 355.120
Elemental Analysis: C, 37.20; H, 5.96; Br, 45.00; N, 11.83

Price and Availability

Size Price Availability Quantity
10mg USD 310 2 Weeks
50mg USD 995 2 Weeks
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Synonym: VUF-5681 dihydrobromide, VUF-5681 2HBr

IUPAC/Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide

InChi Key: YFFVIGXPKWSZHW-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H19N3.2BrH/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10;;/h8-10,12H,1-7H2,(H,13,14);2*1H

SMILES Code: [H]Br.[H]Br.C1(CCCC2=CNC=N2)CCNCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 355.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383

2. Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107 PMID: 15665857

3. Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517 PMID: 16769092