WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 408101
Description: RAMB4, also known as PTP1B-IN-9, is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 selectively reduces the viability of cervical cancer cells independently of HPV genotype via blockade of proteasomal degradation. RAMB4 treatment triggers a Ubiquitin-Proteasome-System (UPS)-stress response without affecting 20S proteasome catalytic activities.
MedKoo Cat#: 408101
Chemical Formula: C19H13Cl4NO
Exact Mass: 410.9751
Molecular Weight: 413.119
Elemental Analysis: C, 55.24; H, 3.17; Cl, 34.32; N, 3.39; O, 3.87
Synonym: PTP1B-IN-9; PTP1B-IN 9; PTP1B-IN9; RAMB4; RAMB-4; RAMB 4;
IUPAC/Chemical Name: (3E,5E)-3,5-Bis(3,4-dichlorobenzylidene)piperidin-4-one
InChi Key: GJPXGFGIFQWUOC-ACFHMISVSA-N
InChi Code: InChI=1S/C19H13Cl4NO/c20-15-3-1-11(7-17(15)22)5-13-9-24-10-14(19(13)25)6-12-2-4-16(21)18(23)8-12/h1-8,24H,9-10H2/b13-5+,14-6+
SMILES Code: O=C1/C(CNC/C1=C\C2=CC=C(Cl)C(Cl)=C2)=C/C3=CC=C(Cl)C(Cl)=C3
Cervical cancer cells exhibit an increased requirement for ubiquitin-dependent protein degradation associated with an elevated metabolic turnover rate, and for specific signaling pathways, notably HPV E6-targeted degradation of p53 and PDZ proteins. Natural compounds with antioxidant properties including flavonoids and triterpenoids hold promise as anticancer agents by interfering with ubiquitin-dependent protein degradation. An increasing body of evidence indicates that their α-β unsaturated carbonyl system is the molecular determinant for inhibition of ubiquitin-mediated protein degradation up-stream of the catalytic sites of the 20S proteasome.
1 . Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.