WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 408100
Description: LQZ-7I is a malarial protease PfSUB1 inhibitor. LQZ-7I showed significantly improved activity and is the focus of this work. LQZ-7 when given orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors. The data obtained utilizing LQZ-7I in both in vitro and in vivo studies highlights its potential as a lead for further development, which may yield a potential cancer therapeutic by targeting the survivin protein directly.
MedKoo Cat#: 408100
Chemical Formula: C20H14F2N4
Exact Mass: 348.1187
Molecular Weight: 348.3568
Elemental Analysis: C, 68.96; H, 4.05; F, 10.91; N, 16.08
Synonym: LQZ-7I; LQZ 7I; LQZ7I;
IUPAC/Chemical Name: 2,3-Quinoxalinediamine, N,N'-bis(4-fluorophenyl)-
InChi Key: DKPCKOKYSVPFEB-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14F2N4/c21-13-5-9-15(10-6-13)23-19-20(24-16-11-7-14(22)8-12-16)26-18-4-2-1-3-17(18)25-19/h1-12H,(H,23,25)(H,24,26)
SMILES Code: FC1=CC=C(NC2=NC3=CC=CC=C3N=C2NC4=CC=C(F)C=C4)C=C1
Survivin, a homodimeric member of the Inhibitor of Apoptosis Protein (IAP) family, is required for cancer cell survival and overexpressed in almost all solid tumors. However, targeting survivin has been challenging due to its “undruggable” nature.
1. Peery, Robert; Kyei-Baffour, Kwaku; Dong, Zizheng; Liu, Jianguo; de Andrade Horn, Pedro; Dai, Mingji; Liu, Jing-Yuan; Zhang, Jian-Ting Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation, Journal of Medicinal Chemistry (2020), Ahead of Print