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MedKoo CAT#: 555802

CAS#: 218136-59-5

Description: SC-26196 is a D6D inhibitor (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to arachidonic acid (AA). SC-26196 inhibited the desaturation of 2 microM [1-14C] 18:2n-6 by 87-95% in cultured human skin fibroblasts, coronary artery smooth muscle cells, and astrocytes. By contrast, SC-26196 did not affect the conversion of [1-14C]20:3n-6 to 20:4 in the fibroblasts, demonstrating that it is selective for delta6-desaturase.

Price and Availability

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 5250 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-07. Prices are subject to change without notice.

SC-26196 is in stock.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 555802
Name: SC-26196
CAS#: 218136-59-5
Chemical Formula: C27H29N5
Exact Mass: 423.2423
Molecular Weight: 423.564
Elemental Analysis: C, 76.56; H, 6.90; N, 16.53

Synonym: SC-26196; SC 26196; SC26196;

IUPAC/Chemical Name: (E)-2,2-diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile




Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


This message contains search results from the National Center for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM). Do not reply directly to this message

Sent On: Mon Jun 15 11:18:28 2020

10 selected items

PubMed Results
Items 1-10 of 10 (Display the 10 citations in PubMed)

1: Wang J, Liang H, Sun M, Zhang L, Xu H, Liu W, Li Y, Zhou Y, Li Y, Li M. Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo. Cancer Manag Res. 2018 Dec 7;10:6779-6790. doi: 10.2147/CMAR.S185601. PMID: 30584371; PMCID: PMC6289123.

2: Sibbons CM, Irvine NA, Pérez-Mojica JE, Calder PC, Lillycrop KA, Fielding BA, Burdge GC. Polyunsaturated Fatty Acid Biosynthesis Involving Δ8 Desaturation and Differential DNA Methylation of FADS2 Regulates Proliferation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2018 Mar 5;9:432. doi: 10.3389/fimmu.2018.00432. PMID: 29556240; PMCID: PMC5844933.

3: Mulligan CM, Le CH, deMooy AB, Nelson CB, Chicco AJ. Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):799-809. doi: 10.1093/gerona/glt209. Epub 2014 Jan 13. PMID: 24418793; PMCID: PMC4111632.

4: Zhang L, Ramtohul Y, Gagné S, Styhler A, Wang H, Guay J, Huang Z. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76. doi: 10.1177/1087057109356208. Epub 2010 Jan 19. PMID: 20086206.

5: Hargrave-Barnes KM, Azain MJ, Miner JL. Conjugated linoleic acid-induced fat loss dependence on Delta6-desaturase or cyclooxygenase. Obesity (Silver Spring). 2008 Oct;16(10):2245-52. doi: 10.1038/oby.2008.338. Epub 2008 Jul 24. PMID: 18719641.

6: Harmon SD, Kaduce TL, Manuel TD, Spector AA. Effect of the delta6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells. Lipids. 2003 Apr;38(4):469-76. doi: 10.1007/s11745-003-1086-9. PMID: 12848296.

7: Duffin KL, Obukowicz MG, Salsgiver WJ, Welsch DJ, Shieh C, Raz A, Needleman P. Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition. Lipids. 2001 Nov;36(11):1203-8. doi: 10.1007/s11745-001-0833-2. PMID: 11795852.

8: Hansen-Petrik MB, McEntee MF, Johnson BT, Obukowicz MG, Masferrer J, Zweifel B, Chiu CH, Whelan J. Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 2002 Jan 25;175(2):157-63. doi: 10.1016/s0304-3835(01)00715-7. PMID: 11741743.

9: Obukowicz M, Welsch D, Salsgiver W, Martin-Berger C, Chinn K, Duffin K, Raz A, Needleman P. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. Lipids. 1999;34 Suppl:S149. doi: 10.1007/BF02562269. PMID: 10419129.

10: Obukowicz MG, Welsch DJ, Salsgiver WJ, Martin-Berger CL, Chinn KS, Duffin KL, Raz A, Needleman P. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J Pharmacol Exp Ther. 1998 Oct;287(1):157-66. PMID: 9765335.