JWH-180

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574367

CAS#: 824959-87-7

Description: JWH-180 is a potent synthetic cannabinoid (CB) that binds both the central CB1 receptor and the peripheral CB2 receptor.

Chemical Structure

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JWH-180
CAS# 824959-87-7
Instruction

Theoretical Analysis

MedKoo Cat#: 574367
Name: JWH-180
CAS#: 824959-87-7
Chemical Formula: C25H25NO
Exact Mass: 355.19
Molecular Weight: 355.480
Elemental Analysis: C, 84.47; H, 7.09; N, 3.94; O, 4.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JWH 180; JWH-180; JWH180

IUPAC/Chemical Name: (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)-methanone

InChi Key: BMOMWXXAVVSIRU-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H25NO/c1-3-9-18-14-15-22(20-11-6-5-10-19(18)20)25(27)23-17-26(16-4-2)24-13-8-7-12-21(23)24/h5-8,10-15,17H,3-4,9,16H2,1-2H3

SMILES Code: O=C(C1=CC=C(CCC)C2=C1C=CC=C2)C3=CN(CCC)C4=C3C=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 355.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists. Bioorg. Med. Chem. 13, 89-112 (2005).

2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).

3. Ernst, L., Schiebel, H.M., Theuring, C., et al. Identification and characterization of JWH-122 used as new ingredient in "spice-like" herbal incenses. Forensic Science International 208(1-3), e31-35 (2011).

4. Uchiyama, N., Kikura-Hanajiri, R., Ogata, J., et al. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Science International 198, 31-38 (2010).