WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574339
CAS#: 360791-49-7
Description: 4BP-TQS is an allosteric agonist of α7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs). 4BP-TQS potentiates acetylcholine-induced activation of α7 subunit-containing nAChRs by greater than 540-fold in X. laevis oocytes.1 It activates wild-type α7 subunit-containing nAChRs and nAChRs containing the α7 subunit and W148F, but not M253L, mutations in X. laevis oocytes.
MedKoo Cat#: 574339
Name: 4BP-TQS
CAS#: 360791-49-7
Chemical Formula: C18H17BrN2O2S
Exact Mass: 404.0194
Molecular Weight: 405.31
Elemental Analysis: C, 53.34; H, 4.23; Br, 19.71; N, 6.91; O, 7.89; S, 7.91
Synonym: 4BP-TQS
IUPAC/Chemical Name: 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
InChi Key: YNCXHXYZTLIZTO-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23)
SMILES Code: NS(C1=CC2=C(C=C1)NC(C3=CC=C(Br)C=C3)C4C2C=CC4)(=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 405.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Gill, J.K., Savolainen, M., Young, G.T., et al. Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc. Natl. Acad. Sci. U.S.A. 108(14), 5867-5872 (2011).
2. Gill, J.K., Chatzidaki, A., Ursu, D., et al. Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors. PLoS One 8(1), e55047 (2013).
