(±)-AC 7954 hydrochloride
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MedKoo CAT#: 574330

CAS#: 477313-09-0

Description: (±)-AC 7954 hydrochloride is a selective nonpeptidic druglike urotensin-II receptor agonist.


Chemical Structure

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(±)-AC 7954 hydrochloride
CAS# 477313-09-0

Theoretical Analysis

MedKoo Cat#: 574330
Name: (±)-AC 7954 hydrochloride
CAS#: 477313-09-0
Chemical Formula: C19H21Cl2NO2
Exact Mass: 365.09
Molecular Weight: 366.280
Elemental Analysis: C, 62.30; H, 5.78; Cl, 19.36; N, 3.82; O, 8.74

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1350 2 Weeks
500mg USD 2950 2 Weeks
1g USD 4650 2 Weeks
2g USD 6950 2 Weeks
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Synonym: (±)-AC 7954 hydrochloride, AC-7954 HCl, AC-7954 hydrochloride

IUPAC/Chemical Name: (±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride

InChi Key: AJPGLOWFIBOGMH-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20ClNO2.ClH/c1-21(2)12-11-19(15-7-9-16(20)10-8-15)13-14-5-3-4-6-17(14)18(22)23-19;/h3-10H,11-13H2,1-2H3;1H

SMILES Code: O=C1C2=CC=CC=C2CC(CCN(C)C)(C3=CC=C(Cl)C=C3)O1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 366.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1) Croston et al (2002) Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 45 4950 PMID: 12408704

2) Lavecchia et al (2005) Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 48 2480 PMID: 15801838