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IACS-6274 free base

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 207126

CAS#: 1853164-83-6 (free base)

Description: IACS-6274, also known as IPN60090, is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities. IPN60090 selectively targets, binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2021-01-21. Prices are subject to change without notice.

IACS-6274 free base is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, SDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 207126
Name: IACS-6274 free base
CAS#: 1853164-83-6 (free base)
Chemical Formula: C24H27F3N8O3
Exact Mass: 532.2158
Molecular Weight: 532.5282
Elemental Analysis: C, 54.13; H, 5.11; F, 10.70; N, 21.04; O, 9.01


Related CAS #: 1853164-83-6 (free base)   2102101-72-2 (HCl)   2102101-77-7 (sulfate)   2102101-78-8 (mesylate)   2102101-80-2 (tosylate)    

Synonym: IACS-6274; IACS 6274; IACS6274; IPN60090; IPN-60090; IPN 60090;

IUPAC/Chemical Name: (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide

InChi Key: GEHZIZWHNLQFAS-OAHLLOKOSA-N

InChi Code: InChI=1S/C24H27F3N8O3/c1-14-7-18(38-19-10-24(26,27)11-19)8-17(29-14)9-22(36)30-21-6-5-16(31-33-21)4-3-15(25)12-35-13-20(32-34-35)23(37)28-2/h5-8,13,15,19H,3-4,9-12H2,1-2H3,(H,28,37)(H,30,33,36)/t15-/m1/s1

SMILES Code: O=C(NC)C1=CN(C[C@H](F)CCC2=CC=C(NC(CC3=CC(OC4CC(F)(F)C4)=CC(C)=N3)=O)N=N2)N=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.