WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 207126
CAS#: 1853164-83-6 (free base)
Description: IACS-6274, also known as IPN60090, is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities. IPN60090 selectively targets, binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate.
MedKoo Cat#: 207126
Name: IACS-6274 free base
CAS#: 1853164-83-6 (free base)
Chemical Formula: C24H27F3N8O3
Exact Mass: 532.2158
Molecular Weight: 532.5282
Elemental Analysis: C, 54.13; H, 5.11; F, 10.70; N, 21.04; O, 9.01
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Related CAS #: 1853164-83-6 (free base) 2102101-72-2 (HCl) 2102101-77-7 (sulfate) 2102101-78-8 (mesylate) 2102101-80-2 (tosylate)
Synonym: IACS-6274; IACS 6274; IACS6274; IPN60090; IPN-60090; IPN 60090;
IUPAC/Chemical Name: (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide
InChi Key: GEHZIZWHNLQFAS-OAHLLOKOSA-N
InChi Code: InChI=1S/C24H27F3N8O3/c1-14-7-18(38-19-10-24(26,27)11-19)8-17(29-14)9-22(36)30-21-6-5-16(31-33-21)4-3-15(25)12-35-13-20(32-34-35)23(37)28-2/h5-8,13,15,19H,3-4,9-12H2,1-2H3,(H,28,37)(H,30,33,36)/t15-/m1/s1
SMILES Code: O=C(NC)C1=CN(C[C@H](F)CCC2=CC=C(NC(CC3=CC(OC4CC(F)(F)C4)=CC(C)=N3)=O)N=N2)N=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 532.5282 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.
