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MedKoo CAT#: 207126
CAS#: 1853164-83-6 (free base)
Description: IACS-6274, also known as IPN60090, is a potent, selective and orally active glutaminase inhibitor with potential antineoplastic and immunostimulating activities. IPN60090 selectively targets, binds to and inhibits human glutaminase, an enzyme that is essential for the conversion of the amino acid glutamine into glutamate.
MedKoo Cat#: 207126
Name: IACS-6274 free base
CAS#: 1853164-83-6 (free base)
Chemical Formula: C24H27F3N8O3
Exact Mass: 532.2158
Molecular Weight: 532.5282
Elemental Analysis: C, 54.13; H, 5.11; F, 10.70; N, 21.04; O, 9.01
Related CAS #: 1853164-83-6 (free base) 2102101-72-2 (HCl) 2102101-77-7 (sulfate) 2102101-78-8 (mesylate) 2102101-80-2 (tosylate)
Synonym: IACS-6274; IACS 6274; IACS6274; IPN60090; IPN-60090; IPN 60090;
IUPAC/Chemical Name: (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide
InChi Key: GEHZIZWHNLQFAS-OAHLLOKOSA-N
InChi Code: InChI=1S/C24H27F3N8O3/c1-14-7-18(38-19-10-24(26,27)11-19)8-17(29-14)9-22(36)30-21-6-5-16(31-33-21)4-3-15(25)12-35-13-20(32-34-35)23(37)28-2/h5-8,13,15,19H,3-4,9-12H2,1-2H3,(H,28,37)(H,30,33,36)/t15-/m1/s1
SMILES Code: O=C(NC)C1=CN(C[C@H](F)CCC2=CC=C(NC(CC3=CC(OC4CC(F)(F)C4)=CC(C)=N3)=O)N=N2)N=N1
Blocking glutamine metabolism inhibits proliferation in rapidly growing tumor cells and leads to an induction of cell death. Unlike normal healthy cells, glutamine-dependent tumors heavily rely on the intracellular conversion of exogenous glutamine into glutamate and glutamate metabolites to provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival.