Galnon trifluoroacetate salt | CAS# 1217448-19-5 | GAL receptor

Galnon trifluoroacetate salt
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462130

CAS#: 1217448-19-5

Description: Galnon is a galanin (GAL) receptor agonist. It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes.

Chemical Structure

Galnon trifluoroacetate salt

CAS# 1217448-19-5

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462130
Name: Galnon trifluoroacetate salt
CAS#: 1217448-19-5
Chemical Formula: C42H47F3N4O8
Exact Mass: 792.33
Molecular Weight: 792.853
Elemental Analysis: C, 63.63; H, 5.98; F, 7.19; N, 7.07; O, 16.14

Price and Availability

Size	Price	Availability
1mg	USD 205	2 Weeks
5mg	USD 365	2 Weeks
10mg	USD 575	2 Weeks
25mg	USD 885	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Galnon trifluoroacetate salt, Galnon TFA

IUPAC/Chemical Name: 3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide, trifluoroacetate salt

InChi Key: MTMBHUMNSQJCNR-WDAFUDAASA-N

InChi Code: InChI=1S/C40H46N4O6.C2HF3O2/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)44(35(38(42)46)17-9-10-20-41)39(47)34(22-26-11-3-2-4-12-26)43-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33;3-2(4,5)1(6)7/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H2,42,46)(H,43,48);(H,6,7)/t34-,35-;/m0./s1

SMILES Code: NCCCC[C@@H](C(N)=O)N(C([C@H](CC1CCCCC1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O)=O)C5=CC=C(C(O6)=C5)C(C)=CC6=O.O=C(O)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Non-selective galanin receptor agonist.
In vitro activity:	In vitro, galnon and galanin showed affinity for human galanin receptors expressed in Bowes melanoma cells (K(i)=5.5 microM and 0.2 nM, respectively). Galnon (10 microM) showed affinity for NPY1, NK2, M5, and somatostatin receptors but no affinity for galanin receptors expressed in rat hippocampal membranes. Reference: Neuropeptides. 2007 Oct;41(5):307-20. https://pubmed.ncbi.nlm.nih.gov/17637475/
In vivo activity:	Administration of galnon (1 microM) in rats significantly attenuated the LTP induction by 85.5 +/- 1% by 51 min after high frequency trains stimulation. Reference: Neuropeptides. 2005 Jun;39(3):249-51. https://pubmed.ncbi.nlm.nih.gov/15944018/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	10.0	12.61
	DMSO:PBS (pH 7.2) (1:2)	0.3	0.38
	DMF	10.0	12.61

Preparing Stock Solutions

The following data is based on the product molecular weight 792.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides. 2007 Oct;41(5):307-20. doi: 10.1016/j.npep.2007.05.001. Epub 2007 Jul 16. PMID: 17637475. 2. McGowan HW, Schuijers JA, Grills BL, McDonald SJ, McDonald AC. Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model. J Musculoskelet Neuronal Interact. 2014 Jun;14(2):162-72. PMID: 24879020. 3. Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T. Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides. 2005 Jun;39(3):249-51. doi: 10.1016/j.npep.2004.12.010. Epub 2005 Mar 19. PMID: 15944018.
In vitro protocol:	1. Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides. 2007 Oct;41(5):307-20. doi: 10.1016/j.npep.2007.05.001. Epub 2007 Jul 16. PMID: 17637475.
In vivo protocol:	1. McGowan HW, Schuijers JA, Grills BL, McDonald SJ, McDonald AC. Galnon, a galanin receptor agonist, improves intrinsic cortical bone tissue properties but exacerbates bone loss in an ovariectomised rat model. J Musculoskelet Neuronal Interact. 2014 Jun;14(2):162-72. PMID: 24879020. 2. Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T. Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice. Neuropeptides. 2005 Jun;39(3):249-51. doi: 10.1016/j.npep.2004.12.010. Epub 2005 Mar 19. PMID: 15944018.

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1: Saar, K., Mazarati, A.M., Mahlapuu, R., et al. Anticonvulsant activity of a nonpeptide galanin receptor agonist. Proc. Natl. Acad. Sci. USA 99(10), 7136-7141 (2002).

2: Ogbonmwan, Y.E., Sciolino, N.R., Groves-Chapman, J.L., et al. The galanin receptor agonist, galnon, attenuates cocaine-induced reinstatement and dopamine overflow in the frontal cortex. Addict. Biol. 20(4), 701-713 (2015).

3: Abramov, U., Florén, A., Echevarria, D.J., et al. Regulation of feeding by galnon. Neuropeptides 38(1), 55-61 (2004).

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