KAA-276 free base

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MedKoo CAT#: 462094

CAS#: 167264-16-6 (free base)

Description: KAA-276 free base is a novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.


Chemical Structure

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KAA-276 free base
CAS# 167264-16-6 (free base)

Theoretical Analysis

MedKoo Cat#: 462094
Name: KAA-276 free base
CAS#: 167264-16-6 (free base)
Chemical Formula: C31H35FN4O2
Exact Mass: 514.2744
Molecular Weight: 514.6454
Elemental Analysis: C, 72.35; H, 6.86; F, 3.69; N, 10.89; O, 6.22

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 167264-26-8 (HCl)   167264-16-6 (free base)  

Synonym: KAA-276 free base

IUPAC/Chemical Name: Benzenepropanoic acid, 4-(2-(5-(1-((4-fluorophenyl)methyl)-1H-benzimidazol-2-yl)hexahydro-1,5-diazocin-1(2H)-yl)ethyl)-

InChi Key: ZZIFWXAFPRAGSH-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H35FN4O2/c32-27-14-11-26(12-15-27)23-36-29-6-2-1-5-28(29)33-31(36)35-20-3-18-34(19-4-21-35)22-17-25-9-7-24(8-10-25)13-16-30(37)38/h1-2,5-12,14-15H,3-4,13,16-23H2,(H,37,38)

SMILES Code: O=C(O)CCC1=CC=C(CCN2CCCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CCC2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 514.6454 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kobayashi T, Takehana Y, Shinagawa K, Tsuyuki S, Tokutake Y, Sato M, Momose D. Pharmacological characterization of a novel long-acting histamine H1 receptor antagonist, KAA-276. Biol Pharm Bull. 1998 Apr;21(4):350-5. doi: 10.1248/bpb.21.350. PMID: 9586571.

2: Kobayashi T, Takehana Y, Shinagawa K, Tsuyuki S, Tokutake Y, Sato M, Momose D. Effects of inhaled KAA-276, a selective histamine H1 receptor antagonist, on antigen- and histamine-induced bronchoconstriction in animals. Arzneimittelforschung. 1998 Aug;48(8):826-31. PMID: 9748711.