JCN037
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462076

CAS#: 2305154-31-6

Description: JCN037 is a potent brain-penetrant EGFR tyrosine kinase inhibitor against malignant brain tumors. JCN037 displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.


Chemical Structure

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JCN037
CAS# 2305154-31-6

Theoretical Analysis

MedKoo Cat#: 462076
Name: JCN037
CAS#: 2305154-31-6
Chemical Formula: C16H11BrFN3O2
Exact Mass: 375.0019
Molecular Weight: 376.1854
Elemental Analysis: C, 51.09; H, 2.95; Br, 21.24; F, 5.05; N, 11.17; O, 8.51

Price and Availability

Size Price Availability Quantity
50.0mg USD 750.0 2 Weeks
100.0mg USD 1250.0 2 Weeks
200.0mg USD 1850.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3450.0 2 Weeks
2.0g USD 5450.0 2 Weeks
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Synonym: JCN-037; JCN037; JCN 037

IUPAC/Chemical Name: N-(3-bromo-2-fluorophenyl)-7,8-dihydro-[1,4]dioxino[2,3-g]quinazolin-4-amine

InChi Key: MTLUFWWVOINWEL-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H11BrFN3O2/c17-10-2-1-3-11(15(10)18)21-16-9-6-13-14(23-5-4-22-13)7-12(9)19-8-20-16/h1-3,6-8H,4-5H2,(H,19,20,21)

SMILES Code: FC1=C(Br)C=CC=C1NC2=C3C=C(OCCO4)C4=CC3=NC=N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 376.1854 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Jonathan E. Tsang, Lorenz M. Urner, Gyudong Kim, Kingsley Chow, Lynn Baufeld, Kym Faull, Timothy F. Cloughesy, Peter M. Clark, Michael E. Jung, and David A. Nathanson. Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.9b00599

JCN037

10.0mg / Not available