WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 462069
Description: JT86 is a highly potent HDAC inhibitor with IC50 0.7 nM. JT86 is an achiral AR-42 analogues incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs, 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86 was ninefold more potent than racAR-42 inpromoting accumulation of acetylated histone H4 in MM96L melanoma cells.
MedKoo Cat#: 462069
Chemical Formula: C23H22N2O4
Exact Mass: 390.158
Molecular Weight: 390.439
Elemental Analysis: C, 70.75; H, 5.68; N, 7.18; O, 16.39
This product is not in stock, which may be available by custom synthesis.
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Synonym: JT-86; JT 86; JT86
IUPAC/Chemical Name: N-(4-(hydroxycarbamoyl)phenyl)-4-(naphthalen-2-yl)tetrahydro-2H-pyran-4-carboxamide
InChi Key: VNRCXPZNHIIBGH-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H22N2O4/c26-21(25-28)17-6-9-20(10-7-17)24-22(27)23(11-13-29-14-12-23)19-8-5-16-3-1-2-4-18(16)15-19/h1-10,15,28H,11-14H2,(H,24,27)(H,25,26)
SMILES Code: O=C(C1(C2=CC=C3C=CC=CC3=C2)CCOCC1)NC4=CC=C(C(NO)=O)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 390.439 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Tng J, Lim J, Wu KC, et al. Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation [published online ahead of print, 2020 May 21]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00230. doi:10.1021/acs.jmedchem.0c00230