WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462069

CAS#: unknown

Description: JT86 is a highly potent HDAC inhibitor with IC50 0.7 nM. JT86 is an achiral AR-42 analogues incorporating a cycloalkyl group linked via a quaternary carbon atom, with up to 40-fold increased potency against human class I HDACs, 25-fold increased cytotoxicity against five human cancer cell lines, and up to 70-fold less toxicity in normal human cells. JT86 was ninefold more potent than racAR-42 inpromoting accumulation of acetylated histone H4 in MM96L melanoma cells.

Chemical Structure

CAS# unknown

Theoretical Analysis

MedKoo Cat#: 462069
Name: JT86
CAS#: unknown
Chemical Formula: C23H22N2O4
Exact Mass: 390.158
Molecular Weight: 390.439
Elemental Analysis: C, 70.75; H, 5.68; N, 7.18; O, 16.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JT-86; JT 86; JT86

IUPAC/Chemical Name: N-(4-(hydroxycarbamoyl)phenyl)-4-(naphthalen-2-yl)tetrahydro-2H-pyran-4-carboxamide


InChi Code: InChI=1S/C23H22N2O4/c26-21(25-28)17-6-9-20(10-7-17)24-22(27)23(11-13-29-14-12-23)19-8-5-16-3-1-2-4-18(16)15-19/h1-10,15,28H,11-14H2,(H,24,27)(H,25,26)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 390.439 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tng J, Lim J, Wu KC, et al. Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation [published online ahead of print, 2020 May 21]. J Med Chem. 2020;10.1021/acs.jmedchem.0c00230. doi:10.1021/acs.jmedchem.0c00230