Teclozan | CAS#5560-78-1 | antiprotozoal agent

Teclozan
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 462046

CAS#: 5560-78-1

Description: Teclozan, also known as WIN 13146, is an antiprotozoal agent. It is a dichloroacetamide.

Chemical Structure

Teclozan

CAS# 5560-78-1

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 462046
Name: Teclozan
CAS#: 5560-78-1
Chemical Formula: C20H28Cl4N2O4
Exact Mass: 500.08
Molecular Weight: 502.254
Elemental Analysis: C, 47.83; H, 5.62; Cl, 28.23; N, 5.58; O, 12.74

Price and Availability

Size	Price	Availability
5mg	USD 150	Ready to ship
10mg	USD 250	Ready to ship
25mg	USD 450	Ready to ship
50mg	USD 750	Ready to ship
100mg	USD 1350	Ready to ship
200mg	USD 2450	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Teclozan; Falmonox; Teclosine; Teclozine; NSC 107433; Teclosan; Teclosine; Win 13146; Win-13146; Win13146; Win-AM 13146;

IUPAC/Chemical Name: Acetamide, N,N'-(1,4-phenylenebis(methylene))bis(2,2-dichloro-N-(2-ethoxyethyl)-

InChi Key: MSJLJWCAEPENBL-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H28Cl4N2O4/c1-3-29-11-9-25(19(27)17(21)22)13-15-5-7-16(8-6-15)14-26(10-12-30-4-2)20(28)18(23)24/h5-8,17-18H,3-4,9-14H2,1-2H3

SMILES Code: O=C(N(CC1=CC=C(CN(CCOCC)C(C(Cl)Cl)=O)C=C1)CCOCC)C(Cl)Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#S21S11C21

QC Data:

View QC data: current batch, Lot#S21S11C21

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	Teclozan (WIN 13146) is an antiprotozoal agent that intervenes in the phospholipid metabolism, preventing the formation of arachidonic acid.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	62.5	124.44

Preparing Stock Solutions

The following data is based on the product molecular weight 502.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Antiamoebic drugs for treating amoebic colitis Maria Liza M Gonzales, Leonila F Dans, Juliet Sio‐Aguilar
Cochrane Database Syst Rev. 2019 Jan; 2019(1): CD006085. Published online 2019 Jan 9. doi: 10.1002/14651858.CD006085.pub3 PMCID: PMC6326239

2: Intestinal parasites. R Knight, M G Schultz, D W Hoskins, P D Marsden Gut. 1973 Feb; 14(2): 145–168. doi: 10.1136/gut.14.2.145 PMCID: PMC1412563

3: Comparative genomics identifies potential virulence factors in Clostridium tertium and C. paraputrificum Marina Muñoz, Daniel Restrepo-Montoya, Nitin Kumar, Gregorio Iraola, Giovanny Herrera, Dora I. Ríos Chaparro, Diana Díaz-Arévalo, Manuel A. Patarroyo, Trevor D. Lawley, Juan David Ramírez Virulence. 2019; 10(1): 657–676. Published online 2019 Jul 13. doi: 10.1080/21505594.2019.1637699 PMCID: PMC6629180

4: Parasite-related diarrhoeas WHO Scientific Working Group Bull World Health Organ. 1980; 58(6): 819–830.
PMCID: PMC2396014

5: Flavonoids as a Natural Treatment Against Entamoeba histolytica Moisés Martínez-Castillo, Judith Pacheco-Yepez, Nadia Flores-Huerta, Paula Guzmán-Téllez, Rosa A. Jarillo-Luna, Luz M. Cárdenas-Jaramillo, Rafael Campos-Rodríguez, Mineko Shibayama Front Cell Infect Microbiol. 2018; 8: 209. Published online 2018 Jun 22. doi: 10.3389/fcimb.2018.00209 PMCID: PMC6024094

6: Availability of essential medicines in primary health care of the Brazilian Unified Health System Renata Cristina Rezende Macedo do Nascimento, Juliana Álvares, Augusto Afonso Guerra, Junior, Isabel Cristina Gomes, Ediná Alves Costa, Silvana Nair Leite, Karen Sarmento Costa, Orlando Mario Soeiro, Ione Aquemi Guibu, Margô Gomes de Oliveira Karnikowski, Francisco de Assis Acurcio Rev Saude Publica. 2017; 51(Suppl 2): 10s.
Published online 2017 Sep 22. doi: 10.11606/S1518-8787.2017051007062 PMCID: PMC5676352

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