Bamirastine
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MedKoo CAT#: 462022

CAS#: 215529-47-8

Description: Bamirastine is a the dihydrate, an antiallergic agent, and NSAID. It inhibits ligand binding to recombinant human histamine H1 receptors (rhH1R).


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-25. Prices are subject to change without notice.

Bamirastine purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and SDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 462022
Name: Bamirastine
CAS#: 215529-47-8
Chemical Formula: C31H37N5O3
Exact Mass: 527.2896
Molecular Weight: 527.669
Elemental Analysis: C, 70.56; H, 7.07; N, 13.27; O, 9.10


Synonym: Bamirastine; TAK 427; TAK-427

IUPAC/Chemical Name: 2-(6-((3-(4-(Diphenylmethoxy)piperidin-1-yl)propyl)amino)imidazo(1,2-b)pyridazin-2-yl)-2-methylpropanoic acid

InChi Key: WTBRUSNNZKWTMI-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H37N5O3/c1-31(2,30(37)38)26-22-36-28(33-26)15-14-27(34-36)32-18-9-19-35-20-16-25(17-21-35)39-29(23-10-5-3-6-11-23)24-12-7-4-8-13-24/h3-8,10-15,22,25,29H,9,16-21H2,1-2H3,(H,32,34)(H,37,38)

SMILES Code: CC(C)(C1=CN2N=C(NCCCN3CCC(OC(C4=CC=CC=C4)C5=CC=CC=C5)CC3)C=CC2=N1)C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Oxazolone-Induced Delayed Type Hypersensitivity Reaction in the Adult Yucatan Pigs. A Useful Model for Drug Development and Validation Samer Nuhaily, Bassam B. Damaj, Azzam A. Maghazachi Toxins (Basel) 2009 Sep; 1(1): 25–36. Published online 2009 Aug 21. doi: 10.3390/toxins1010025 PMCID: PMC3202774

2: Effects of Bifidobacterium bifidum G9-1 on Nasal Symptoms in a Guinea Pig Model of Experimental Allergic Rhinitis Satoru TSUNEMINE, Yasuhiro ISA, Masaki SHIMAKAWA, Hiroshi OHNO, Hideki YAMAMURA Biosci Microflora. 2011; 30(1): 1–7. Published online 2010 Feb 18. doi: 10.12938/bifidus.30.1 PMCID: PMC4103633

3: NOD2 and TLR2 ligands trigger the activation of basophils and eosinophils by interacting with dermal fibroblasts in atopic dermatitis-like skin inflammation Delong Jiao, Chun-Kwok Wong, Huai-Na Qiu, Jie Dong, Zhe Cai, Man Chu, Kam-Lun Hon, Miranda Sin-Man Tsang, Christopher Wai-Kei Lam Cell Mol Immunol. 2016 Jul; 13(4): 535–550. Published online 2015 Sep 21. doi: 10.1038/cmi.2015.77 PMCID: PMC4947824

4: Herbex-kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats Anil Kumar, Rawal Prasad, Nanjan Mulla Jogge, Suresh Bhojraj, Solomon F. Emerson, S. Prabakar Evid Based Complement Alternat Med. 2008 Sep; 5(3): 289–294. Published online 2007 May 17. doi: 10.1093/ecam/nem034 PMCID: PMC2529394